New Methods for Green Organic Synthesis

绿色有机合成新方法

• 批准号: RGPIN-2017-04272
• 负责人: Ollevier, Thierry
• 金额: $ 2.55万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632774
• 关键词: New; Methods; Green; Organic; Synthesis

Our proposal focuses on the development of iron and bismuth-derived Lewis acids as green catalysts. Their use in synthetic chemistry needs to be further developed because they are environmentally benign, relatively nontoxic and economic in comparison to other metals. The objective of our research is the development of new synthetic methods, with emphasis on catalytic and enantioselective procedures for the straightforward preparation of molecules of pharmaceutical interest. Catalytic asymmetric processes are indispensable for producing enantiomerically enriched compounds in modern organic synthesis, providing more economical and environmentally benign processes than methods requiring stoichiometric amounts of chiral reagents. Our results will lead to new tools for the preparation of molecules of biological interest. These studies will contribute to the development of new green synthetic methods using environmentally friendly and more economical Lewis acid catalysts.

我们的建议集中在铁和铋衍生的刘易斯酸作为绿色催化剂的发展。它们在合成化学中的用途需要进一步开发，因为与其他金属相比，它们对环境无害，相对无毒且经济。我们的研究目标是开发新的合成方法，重点是催化和对映选择性程序，用于直接制备具有药用价值的分子。催化不对称方法是现代有机合成中制备对映体富集化合物不可或缺的方法，与需要化学计量的手性试剂的方法相比，它提供了更经济和环境友好的方法。我们的研究结果将为制备生物学感兴趣的分子提供新的工具。这些研究将有助于开发使用环境友好和更经济的刘易斯酸催化剂的新的绿色合成方法。