New methods for synthetic organic chemistry

本研究组的主要研究目标是开发新的合成方法，重点是简单直接地制备生物学和商业上重要分子的催化对映选择性过程。该项目的具体目标是开发使用铋（III）盐的催化反应。由于铋伊萨一种廉价无毒的元素，我们希望探索铋盐的催化作用。此外，刘易斯酸能够在温和和环境友好的条件下催化对映选择性反应，这对合成化学家来说是一个巨大的挑战。本项目的创新元素是使用铋（III）盐催化对映选择性反应的发展。文献中出现了非常有限的涉及催化不对称Mukaiyama羟醛缩合反应的例子。在这种情况下，显然需要开发廉价、易于处理和足够刘易斯酸性的新手性铋（III）催化剂。我们希望将铋（III）催化的不对称有机合成的研究拓展到Mannich型反应中，本研究项目福尔斯属于铋（III）催化的不对称有机合成研究领域。这一领域非常重要，因为它使加拿大在制药和精细化学工业方面处于卓越水平。我们拟议的研究计划将有助于培养合成有机化学和药物化学领域的高度专业化人才。

The primary research objective in my group is the development of new synthetic methods, with emphasis oncatalytic enantioselective procedures for the simple and straightforward preparation of biologically andcommercially important molecules. The specific aims of this project involve the development of catalyticreactions using bismuth(III) salts. We wish to explore the catalytic effects of bismuth salts because bismuth isa cheap and non-toxic element. Moreover, Lewis acids able to catalyze enantioselective reactions under mildand environmentally benign conditions represent an extraordinary challenge for the synthetic chemist.The innovative element of this project is the development of catalytic enantioselective reactions usingbismuth(III) salts. Very limited examples have appeared in the literature involving catalytic asymmetric Mukaiyama aldol reactions. In this context, there is clearly a need for the development of new chiral bismuth(III) catalysts that are cheap, easy to handle, and sufficiently Lewis acidic. We wish to extend the development of a bismuth(III) based enantioselective procedure to the Mannich-type reaction.The project presented here falls within a research field of asymmetric organic synthesis using a bismuth(III) catalyst. This field is of significant importance as it has placed Canada at a level of excellence in the pharmaceutical and fine chemistry industry. Our proposed research program will contribute to the training of highly specialized personnel in the sectors of synthetic organic and medicinal chemistry.