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Synthesis of Novel Indole-Based Heterocycles

新型吲哚基杂环化合物的合成

基本信息

批准号：
RGPIN-2015-05365
负责人：
Jha, Mukund
金额：
$ 1.46万
依托单位：
Nipissing University
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2017
资助国家：
加拿大
起止时间：
2017-01-01 至 2018-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632802
关键词：
Synthesis Novel Indole Based Heterocycles

项目摘要

Creative organic synthesis is a cornerstone for feeding thedemands of numerous research areas (such as pharmaceuticals, agrochemicals,material sciences, catalysis, photochemistry, fragrances and pigments) wherenovel molecular frameworks with interesting properties and topology areconstantly sought. It is crucial for synthetic chemists to develop andfine-tune reaction methodologies that enable efficient and green synthesis ofthe desired skeletons. The indole core is a prevalent substructure in manynatural products and biologically active compounds. Due to its biologicalimportance, indole based compounds attract special attention as a buildingblock for the development of therapeutic agents by medicinal chemists. Aplethora of bioactivities surrounding the indole-core continue to be a drivingforce in the development of new methodology to find useful compounds andincrease the heterocyle diversity. Thus, the need for development of efficientand practical syntheses of indoles bearing a variety of substitution patternsis of great significance. The objective of my research program is to exploreand develop novel and efficient synthetic methodology of indole heterocyclesbearing a variety of substitution patterns. The long-term goal is to use thedeveloped methodology to enrich the heterocycle diversity around indole nucleusto find commercially useful chemicals.

创造性有机合成是满足众多研究领域（如制药、农用化学品、材料科学、催化、光化学、香料和颜料）需求的基石，这些领域不断寻求具有有趣性质和拓扑结构的新型分子框架。对于合成化学家来说，开发和微调反应方法，使所需骨架的高效和绿色合成成为可能是至关重要的。吲哚核是许多天然产物和生物活性化合物中普遍存在的一种亚结构。吲哚类化合物由于其重要的生物学意义，作为药物化学家开发治疗药物的基石而受到特别的关注。围绕吲哚核心的大量生物活性继续成为开发新方法以发现有用化合物和增加杂环多样性的驱动力。因此，开发具有多种取代模式的吲哚的有效和实用的合成方法的需要具有重要意义。本课题的研究目标是探索和发展新型高效的吲哚杂环类化合物的合成方法。长期目标是利用已开发的方法来丰富吲哚核周围的杂环多样性，以发现商业上有用的化学品。