Synthesis of Novel Indole-Based Heterocycles

创造性有机合成是满足众多研究领域（如制药、农用化学品、材料科学、催化、光化学、香料和颜料）需求的基石，在这些领域，不断寻求具有有趣性质和拓扑结构的新型分子框架。对于合成化学家来说，开发和调整反应方法以实现所需骨架的高效和绿色合成是至关重要的。吲哚核是许多天然产物和生物活性化合物中普遍存在的亚结构。由于其生物学上的重要性，吲哚类化合物作为药物化学家开发治疗剂的基石而受到特别关注。围绕吲哚核心的大量生物活性继续成为寻找有用化合物和增加杂环多样性的新方法发展的推动力。因此，开发高效实用的吲哚类化合物的合成方法具有重要的意义。我的研究目标是探索和开发具有多种取代模式的吲哚杂环的新颖高效的合成方法。长期目标是利用开发的方法来丰富吲哚核周围的杂环多样性，以发现商业上有用的化学物质。

Creative organic synthesis is a cornerstone for feeding thedemands of numerous research areas (such as pharmaceuticals, agrochemicals,material sciences, catalysis, photochemistry, fragrances and pigments) wherenovel molecular frameworks with interesting properties and topology areconstantly sought. It is crucial for synthetic chemists to develop andfine-tune reaction methodologies that enable efficient and green synthesis ofthe desired skeletons. The indole core is a prevalent substructure in manynatural products and biologically active compounds. Due to its biologicalimportance, indole based compounds attract special attention as a buildingblock for the development of therapeutic agents by medicinal chemists. Aplethora of bioactivities surrounding the indole-core continue to be a drivingforce in the development of new methodology to find useful compounds andincrease the heterocyle diversity. Thus, the need for development of efficientand practical syntheses of indoles bearing a variety of substitution patternsis of great significance. The objective of my research program is to exploreand develop novel and efficient synthetic methodology of indole heterocyclesbearing a variety of substitution patterns. The long-term goal is to use thedeveloped methodology to enrich the heterocycle diversity around indole nucleusto find commercially useful chemicals.