Synthesis of Novel Indole-Based Heterocycles

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Creative organic synthesis is a cornerstone for feeding thedemands of numerous research areas (such as pharmaceuticals, agrochemicals,material sciences, catalysis, photochemistry, fragrances and pigments) wherenovel molecular frameworks with interesting properties and topology areconstantly sought. It is crucial for synthetic chemists to develop andfine-tune reaction methodologies that enable efficient and green synthesis ofthe desired skeletons. The indole core is a prevalent substructure in manynatural products and biologically active compounds. Due to its biologicalimportance, indole based compounds attract special attention as a buildingblock for the development of therapeutic agents by medicinal chemists. Aplethora of bioactivities surrounding the indole-core continue to be a drivingforce in the development of new methodology to find useful compounds andincrease the heterocyle diversity. Thus, the need for development of efficientand practical syntheses of indoles bearing a variety of substitution patternsis of great significance. The objective of my research program is to exploreand develop novel and efficient synthetic methodology of indole heterocyclesbearing a variety of substitution patterns. The long-term goal is to use thedeveloped methodology to enrich the heterocycle diversity around indole nucleusto find commercially useful chemicals.