Synthesis of Novel Indole-Based Heterocycles

新型吲哚基杂环化合物的合成

• 批准号: RGPIN-2015-05365
• 负责人: Jha, Mukund
• 金额: $ 1.46万
• 依托单位: Nipissing University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=654629
• 关键词: Synthesis; Novel; Indole; Based; Heterocycles

* * 0* 0* 1* 292* 1671* Nipissing University* 13* 3* 1960* 14.0* * * * ***** * Normal* 0* * * * * false* false* false* * EN-US* JA* X-NONE* * * * * * * * * * * * * * * * * * * * * * * * * ***** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * ****** /* Style Definitions */*table.MsoNormalTable* {mso-style-name:"Table Normal";* mso-tstyle-rowband-size:0;* mso-tstyle-colband-size:0;* mso-style-noshow:yes;* mso-style-priority:99;* mso-style-parent:"";* mso-padding-alt:0in 5.4pt 0in 5.4pt;* mso-para-margin:0in;* mso-para-margin-bottom:.0001pt;* mso-pagination:widow-orphan;* font-size:12.0pt;* font-family:Cambria;* mso-ascii-font-family:Cambria;* mso-ascii-theme-font:minor-latin;* mso-hansi-font-family:Cambria;* mso-hansi-theme-font:minor-latin;}********Creative organic synthesis is a cornerstone for feeding the*demands of numerous research areas (such as pharmaceuticals, agrochemicals,*material sciences, catalysis, photochemistry, fragrances and pigments) where*novel molecular frameworks with interesting properties and topology are*constantly sought. It is crucial for synthetic chemists to develop and*fine-tune reaction methodologies that enable efficient and green synthesis of*the desired skeletons. The indole core is a prevalent substructure in many*natural products and biologically active compounds. Due to its biological*importance, indole based compounds attract special attention as a building*block for the development of therapeutic agents by medicinal chemists. A*plethora of bioactivities surrounding the indole-core continue to be a driving*force in the development of new methodology to find useful compounds and*increase the heterocyle diversity. Thus, the need for development of efficient*and practical syntheses of indoles bearing a variety of substitution patterns*is of great significance. The objective of my research program is to explore*and develop novel and efficient synthetic methodology of indole heterocycles*bearing a variety of substitution patterns. The long-term goal is to use the*developed methodology to enrich the heterocycle diversity around indole nucleus*to find commercially useful chemicals.***The proposed research program will lead to novel indole-based*molecular architectures with interesting biological properties and 3-D*topology. These molecules could also serve as building blocks for synthesizing*compounds of desired frameworks. Particular attention will be given to*incorporating green properties (such as, clean and quantitative conversion,*mild conditions, catalyst recycling, atom economy, one-pot cascade reactions,*and low waste production) to methodologies developed in my laboratory in*order to advance their practical and commercial importance. Approximately 25-30 students (HQP) will be trained over the tenure of the grant. The training received by HQPs will better prepare them to contribute to research activities in industry, government, and university laboratories across Canada. ********

* * 0 * 0 * 1 * 292 * 1671 * Nipissing大学* 13 * 3 * 1960 * 14.0 * * * * ***** * 正常* 0 * * * * * 假*假*假* * en - us *是* X-NONE * * * * * * * * * * * * * * * * * * * * * * * * * ***** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * ** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * ****** /* 样式定义* / *表。MsoNormalTable* {mso-style-name:"Table Normal"；* mso-tstyle-rowband-size: 0;* mso-tstyle-colband-size: 0;* mso-style-noshow:是的;* mso-style-priority: 99;* mso-style-parent:“”;* font - family：宋体；* mso-para-margin: 0;* mso-para-margin-bottom: .0001pt;* mso-pagination: widow-orphan;*字体大小:12.0分;*字体类型:威尔士;* mso-ascii-font-family:威尔士;* mso-ascii-theme-font: minor-latin;* mso-hansi-font-family:威尔士;* mso-hansi-theme-font: minor-latin;********创造性有机合成是满足众多研究领域（如制药、农用化学品、材料科学、催化、光化学、香料和颜料）需求的基石，在这些领域，不断寻求具有有趣性质和拓扑结构的新型分子框架。对于合成化学家来说，开发和调整反应方法，使所需骨架的高效和绿色合成成为可能是至关重要的。吲哚核心是许多天然产物和生物活性化合物中普遍存在的亚结构。由于其在生物学上的重要性，吲哚类化合物作为药物化学家开发治疗剂的基石，受到了特别的关注。围绕吲哚核心的大量生物活性继续推动着新方法的发展，以发现有用的化合物并增加杂环的多样性。因此，开发具有多种取代构型的吲哚的高效、实用的合成方法具有重要意义。我的研究计划的目标是探索和开发具有多种取代模式的吲哚杂环的新颖高效的合成方法。长期目标是使用开发的方法来丰富吲哚核周围的杂环多样性，以发现商业上有用的化学物质。***拟议的研究计划将导致具有有趣的生物学特性和3-D拓扑结构的新型吲哚基分子结构。这些分子也可以作为合成所需框架化合物的基石。将特别关注将绿色特性（如清洁和定量转化、温和条件、催化剂回收、原子经济、一锅级联反应和低废物产生）与我实验室开发的方法相结合，以提高其实际和商业重要性。大约25-30名学生（HQP）将在资助期间接受培训。hqp接受的培训将使他们更好地为加拿大各地的工业、政府和大学实验室的研究活动做出贡献。＊＊＊＊＊＊＊＊