Nanoprobes to reveal signature biomarkers

纳米探针揭示特征生物标志物

• 批准号: RGPIN-2015-04994
• 负责人: Maysinger, Dusica
• 金额: $ 3.28万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632911
• 关键词: Nanoprobes; reveal; signature; biomarkers

The ability of cells to adapt to different injurious stimuli is one of the major forces driving evolution. The mechanisms underlying cell adaptation are not fully understood. Lysosomes, dynamic cellular organelles which were considered for a long time only “garbage incinerators” have been recently proposed as essential players in cellular adaptation. Lysosomal functions are regulated at transcriptional and posttranscriptional levels and these functions respond to extracellular and intracellular cues. Transcription factor EB (TFEB) is a master regulator of lysosomal functions. Its status depends on upstream kinase activities.

细胞适应不同有害刺激的能力是推动进化的主要力量之一。细胞适应的机制尚未完全了解。溶酶体是一种动态的细胞器，长期以来被认为是“垃圾焚烧炉”，最近被认为是细胞适应的重要参与者。溶酶体的功能在转录和转录后水平上受到调节，这些功能对细胞外和细胞内的信号有反应。转录因子EB（TFEB）是溶酶体功能的主要调节因子。其状态取决于上游激酶活性。