Development of Biomedical Devices for the In Vivo Measurement of Toxic Elements

体内有毒元素测量生物医学设备的开发

• 批准号: RGPIN-2017-06515
• 负责人: McNeill, Fiona
• 金额: $ 2.62万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632943
• 关键词: Development; Biomedical; Devices; Vivo; Measurement

In Canada, people are exposed to a number of toxic elements both medically and environmentally. We often monitor exposure through blood and urine, but these only report recent exposure, while health effects are often a result of long term exposure. In my laboratory, we design and build radiation-based biomedical devices that measure retention and storage of elements in the body. Our devices can be used to assess and monitor health effects linked to chronic exposure. I propose to develop technology for the safe, painless measurement of gadolinium (Gd), chromium (Cr), cobalt (Co), elements that people can be exposed to medically, and for fluorine (F), arsenic (As) and selenium (Se), elements which are in people's drinking water in some areas of Canada.

在加拿大，人们在医学和环境方面都接触到许多有毒元素。我们经常通过血液和尿液监测暴露情况，但这些仅报告最近的暴露情况，而健康影响往往是长期暴露的结果。在我的实验室中，我们设计和制造基于辐射的生物医学设备，用于测量体内元素的保留和储存。我们的设备可用于评估和监测与长期接触相关的健康影响。我建议开发安全、无痛测量钆 (Gd)、铬 (Cr)、钴 (Co)（人们在医学上可能接触到的元素）以及氟 (F)、砷 (As) 和硒 (Se)（加拿大某些地区人们饮用水中存在的元素）的技术。