In vivo measurement of arsenic, aluminum, indium and fluorine

砷、铝、铟和氟的体内测量

• 批准号: 203611-2007
• 负责人: McNeill, Fiona
• 金额: $ 2.39万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=477198
• 关键词: vivo; measurement; arsenic; aluminum; indium

Mining and smelting are extremely important to the Canadian economy. Canada exported $48 billion worth of non-fuel minerals and mineral products in 2000 and is the world's largest producer of uranium, the third largest producer of copper, and produces zinc, lead, cadmium, platinum, indium, aluminum, gold... The economic dependence on this industry means that there are large numbers of Canadian workers exposed to potentially toxic elements and many Canadians exposed environmentally at lower levels. Workers who are known to be exposed are generally monitored by their employer via blood and urine measurements. Workers whose levels increase above certain pre-set limits will be removed from potentially high exposure situations until their levels fall. However, measurement of blood or urine alone does not allow exogenous and endogenous exposures to be separately accounted for, and this can make the interpretation of risk complicated. It also makes the management of workers with extensive employment histories difficult, as they often have body stores of the element which can keep blood and urines elevated even in the absence of external exposure.

采矿和冶炼对加拿大经济极​​为重要。加拿大2000年出口了价值480亿美元的非燃料矿物和矿产品，是世界上最大的铀生产国、第三大铜生产国，并生产锌、铅、镉、铂、铟、铝、金……对这一行业的经济依赖意味着有大量加拿大工人暴露于潜在有毒元素，许多加拿大人暴露在较低水平的环境中。 已知接触过病毒的工人通常由雇主通过血液和尿液测量进行监测。水平升高超过某些预设限制的工人将被从潜在的高暴露环境中移除，直到其水平下降。然而，仅测量血液或尿液并不能单独考虑外源性和内源性暴露，这可能会使风险的解释变得复杂。这也使得对具有广泛工作经历的工人的管理变得困难，因为他们体内经常储存有这种元素，即使在没有外部暴露的情况下，这种元素也可以使血液和尿液保持在较高水平。