In vivo measurement of arsenic, aluminum, indium and fluorine

砷、铝、铟和氟的体内测量

• 批准号: 203611-2007
• 负责人: McNeill, Fiona
• 金额: $ 2.39万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=453403
• 关键词: vivo; measurement; arsenic; aluminum; indium

Mining and smelting are extremely important to the Canadian economy. Canada exported $48 billion worth of non-fuel minerals and mineral products in 2000 and is the world's largest producer of uranium, the third largest producer of copper, and produces zinc, lead, cadmium, platinum, indium, aluminum, gold... The economic dependence on this industry means that there are large numbers of Canadian workers exposed to potentially toxic elements and many Canadians exposed environmentally at lower levels. Workers who are known to be exposed are generally monitored by their employer via blood and urine measurements. Workers whose levels increase above certain pre-set limits will be removed from potentially high exposure situations until their levels fall. However, measurement of blood or urine alone does not allow exogenous and endogenous exposures to be separately accounted for, and this can make the interpretation of risk complicated. It also makes the management of workers with extensive employment histories difficult, as they often have body stores of the element which can keep blood and urines elevated even in the absence of external exposure.

采矿和冶炼对加拿大经济极为重要。2000年，加拿大出口了价值480亿美元的非燃料矿物和矿物产品，是世界上最大的铀生产国，第三大铜生产国，并生产锌、铅、镉、铂、铟、铝、金和其他金属。对这一行业的经济依赖意味着有大量的加拿大工人暴露于潜在的有毒元素，许多加拿大人在环境中暴露的水平较低。 已知接触的工人通常由雇主通过血液和尿液测量进行监测。如果工人的辐射水平超过某些预先设定的限度，将被从潜在的高辐射环境中移除，直到他们的辐射水平下降。然而，仅测量血液或尿液并不能单独说明外源性和内源性接触，这可能使风险的解释变得复杂。这也使得管理具有广泛就业历史的工人变得困难，因为他们通常具有该元素的身体储存，即使在没有外部暴露的情况下，也可以保持血液和尿液升高。