Development of advanced adsorptive separation technology for environmental and biopharmaceutical applications

开发用于环境和生物制药应用的先进吸附分离技术

• 批准号: RGPIN-2017-04510
• 负责人: Zhang, Yan
• 金额: $ 1.75万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638015
• 关键词: Development; advanced; adsorptive; separation; technology

Adsorption and chromatography play a critical role in separating and purifying valuable chemical and biochemical products. High cost of operation and low separation capacity remain the major bottlenecks in their implementation to environmental and biopharmaceutical separations. My research in the past several years has focused on developing new sustainable adsorbents and advanced adsorption-based separation processes. Building on the strengths of past research efforts, the proposed research program aims to address the challenging topics of (i) developing new porous polysaccharide-based adsorbents for selective adsorption and recovery of precious metals; and (ii) exploring new techniques for isolation and purification of therapeutic proteins by preparative liquid chromatography.

吸附和色谱在分离和纯化有价值的化学和生物化学产品中起着关键作用。高运行成本和低分离能力仍然是其应用于环境和生物制药分离的主要瓶颈。在过去的几年里，我的研究重点是开发新的可持续吸附剂和先进的吸附分离工艺。基于过去研究工作的优势，拟议的研究计划旨在解决以下具有挑战性的主题：（i）开发新的多孔多糖基吸附剂，用于选择性吸附和回收贵金属;以及（ii）探索通过制备液相色谱分离和纯化治疗性蛋白质的新技术。