Microparticle Formation Kinetics in Spray Drying

喷雾干燥中的微粒形成动力学

• 批准号: RGPIN-2016-04111
• 负责人: Vehring, Reinhard
• 金额: $ 2.77万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638091
• 关键词: Microparticle; Formation; Kinetics; Spray; Drying

Particle Engineering provides the analytical and theoretical basis for the design of advanced microparticles. These small particles have applications in many fields, e.g. in the chemical and food industries. One application in particular has grown steadily over the last decade, the design of inhalable microparticles for drug delivery to the nose or lung. Several therapeutics based on these particles have entered the market or are in late stage pharmaceutical development. Particle engineering methodology has been implemented in the industrial development process. Advanced microparticles typically have diameters in the range of 0.5 – 50 µm and are structured, i.e. they have functional substructures often in the nanometer scale, which impact important product attributes such as physical and chemical stability, encapsulation, or powder flowability and dispersibility, i.e., the property of a powder that describes how easy it is to disperse it into individual particles.

粒子工程学为先进微粒的设计提供了分析和理论基础。这些小颗粒在许多领域中有应用，例如在化学和食品工业中。在过去的十年中，一个应用特别稳定增长，用于将药物输送到鼻子或肺部的可吸入微粒的设计。基于这些颗粒的几种治疗剂已经进入市场或处于后期药物开发阶段。粒子工程方法学已经在工业发展过程中得到实施。高级微粒通常具有0.5 - 50 μm范围内的直径，并且是结构化的，即它们具有通常在纳米级的功能亚结构，其影响重要的产品属性，例如物理和化学稳定性、封装或粉末流动性和可分散性，即，粉末的性质，描述了将其分散成单个颗粒的容易程度。