Microscale propulsion and pumping in complex fluids

复杂流体中的微尺度推进和泵送

• 批准号: RGPIN-2014-06577
• 负责人: Elfring, Gwynn
• 金额: $ 1.82万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638421
• 关键词: Microscale; propulsion; pumping; complex; fluids

The development of biomimetic synthetic swimming microorganisms (micro-swimmers), opens the door to a wide spectrum of potential applications where very small scales are required. These micro-swimmers could be used to perform internal surgery or drug delivery in the human body, used as autonomous roving chemical sensors or even for microscale assembly. An anchored micro-swimmer can act as a microscale pump, mimicking cilia found in nature, a very effective method for transport and mixing at the cellular scale. A difficulty in the design of these synthetic micro-swimmers and micro-pumps is that the physics of fluids at such small scales is fundamentally different than that of everyday observable phenomena and often quite unintuitive. At these scales viscous forces are dominant and inertia is negligible hence familiar methods of locomotion and pumping can be completely ineffective. A particular challenge in the design of these micro-devices for use in industrial or biological applications is that the relevant fluids are often non-Newtonian. Despite the innovative experimental strides being made in fabricating these biomimetic devices, scientific progress must be made to properly characterize their mechanics in complex systems and fluids. Developing this understanding is critical if these devices are to progress from simply a proof-of-concept to industrial and commercial viability, and it is vital for applications in healthcare. It is proposed here to develop a research program on the mechanics of synthetic micro-swimmers and micro-pumps in complex fluids and systems, including scenarios where the fluid may contain microstructure, and where the interaction of many swimmers (collective motion) may be crucial.

仿生合成游泳微生物（微型游泳者）的发展为需要非常小规模的广泛潜在应用打开了大门。这些微型游泳者可用于在人体内进行内部手术或药物输送，用作自主流动的化学传感器，甚至用于微型组装。锚定的微型游泳者可以作为一个微型泵，模仿自然界中发现的纤毛，这是一种在细胞尺度上进行运输和混合的非常有效的方法。设计这些合成微型游泳者和微型泵的困难在于，在如此小的尺度下的流体物理学与日常可观察到的现象有着根本的不同，并且通常非常不直观。在这些尺度下，粘性力占主导地位，惯性可以忽略不计，因此熟悉的运动和泵送方法可能完全无效。在工业或生物应用中使用的这些微型装置的设计中的一个特别的挑战是，相关的流体通常是非牛顿的。尽管在制造这些仿生设备方面取得了创新的实验进展，但必须取得科学进展，以正确表征它们在复杂系统和流体中的力学特性。如果这些设备要从简单的概念验证发展到工业和商业可行性，发展这种理解是至关重要的，并且对于医疗保健应用至关重要。这里建议开发一个研究计划，在复杂的流体和系统中的合成微型游泳者和微型泵的力学，包括流体可能包含微观结构的场景，以及许多游泳者（集体运动）的相互作用可能是至关重要的。