Subject-Specific 3D Biomechanical and Computational Model of the Femoroacetabular Joint

超过17%的男性和4%的女性患有髋关节和腹股沟疼痛，这是由于股骨头的肿块导致球和髋窝之间的撞击，需要髋大屈曲和外旋。这种情况被称为凸轮股髋臼撞击（FAI）。症状与畸形程度有关，在需要髋关节大活动范围的活动中较早出现。越来越多的证据表明，髋关节骨畸形有助于早期成人髋关节骨关节炎（OA）的发展。尽管cam FAI的原因尚不清楚，但由于股骨头头颈交界处和髋窝边缘之间的高机械应力而导致的骨重塑改变可能是危险因素之一。最终目标是了解凸轮FAI的进展，本研究计划的主要目标将包括开发受试者特定的3D生物力学和髋关节计算模型，以估计个体肌肉力量，髋关节接触负荷，以及参与者进行日常生活活动时骨骼和软骨的主要应力和应变成分。两种模型将应用于三组参与者：症状性FAI受试者；无症状FAI受试者；年龄、体重和身高匹配的对照组，在日常剧烈活动中没有下肢异常。将特定主题的肌肉解剖、髋关节中心和特定任务的运动分析结合起来，创建肌肉骨骼模型，使这项研究成为生物力学领域独特的、原创的、雄心勃勃的贡献。软骨下骨变硬的假设对软骨脱层的过程和骨性关节炎的发展起力学作用。使用特定的有限元参数估计具有凸轮FAI的髋关节的峰值机械应力将确定软骨下板的机械载荷对髋关节的病理机制的影响。大型数据集将允许测试模型的可靠性和鲁棒性，这通常是文献中缺乏的。

More than 17% of men and 4% of women suffer from hip and groin pain due to a bump at the femoral head causing impingement between the ball and hip socket for activities requiring large hip flexion and external rotation. This condition is named cam femoroacetabular impingement (FAI). Symptoms are related to the degree of deformities and occur earlier in the presence of activities requiring high range of motion of the hip joint. Increasing evidence suggests that hip bone deformity contributes to the development of early adult hip osteoarthritis (OA). Although the causes of cam FAI remains unknown, the alteration of bone remodelling due to high mechanical stresses between the head-neck junction of the femoral head and the hip socket's rim could be one of the risk factors. With the ultimate goal is to understand the progression of cam FAI, the main goal of this research program will consist of developing subject-specific, 3D biomechanical and computational models of the hip to estimate individual muscle forces, hip contact loadings, as well as principal stress and strain components of the bone and cartilage in participants performing daily living activities. Both models will be applied to three groups of participants: symptomatic FAI subjects; asymptomatic FAI subjects; and age-, weight-, and height-matched controls, where no lower limb abnormalities are present during strenuous activities of daily living. The integration of subject-specific muscle anatomy, hip joint center, and tasks-specific motion analyses for the creation of a musculo-skeletal model makes this research a unique, original, ambitious contribution to the field of biomechanics. The assumption of the stiffening of the subchondral bone plays a mechanical role towards the process of cartilage delamination and then the development of OA. The estimation of peak mechanical stresses in a hip with cam FAI using subject specific parameters for the FEM would identify the effect of mechanical loading of the subchondral plate on the pathomechanism of the hip joint. The large dataset will allow testing the reliability and robustness of the models, which is usually lacking in literature.