Mechanics of Knee Joints - The Role of Fluid Pressure and Flow in Load Sharing and Cartilage Metabolism

关节软骨和半月板对膝关节的正常机械功能至关重要。这些软组织由65-80%的液体组成。在日常活动中，膝关节受到挤压会引起这些组织的液体流动。软骨代谢也受到滑液的调节，滑液为软骨细胞带来营养。此外，流体压力可以支撑超过50%的膝关节负荷。因此，为了了解正常的膝关节力学功能，有必要充分发现软骨和半月板中流体压力和流动的力学和生物学功能。目前，由于在膝关节内流体压力测量和膝关节解剖准确模型的流体压力预测方面存在困难，这方面的信息非常有限。

Articular cartilage and meniscus are essential for the normal mechanical function of the knee joint. These soft tissues are comprised of 65-80% fluid. Fluid flow is induced in these tissues by knee compressions during daily activities. Cartilage metabolism is also regulated by the synovial fluid, which brings nutrients to cartilage cells. Furthermore, fluid pressure can support over 50% of the knee load. Therefore, it is necessary to fully discover the mechanical and biological functions of fluid pressure and flow in cartilage and meniscus in order to understand normal knee mechanical functions. Currently, this information is very limited due to difficulties in both fluid pressure measurements inside the knee and fluid pressure predictions with an anatomically accurate model of the knee joint.