Mechanics of Knee Joints - The Role of Fluid Pressure and Flow in Load Sharing and Cartilage Metabolism
膝关节力学 - 流体压力和流量在负荷分配和软骨代谢中的作用
基本信息
- 批准号:RGPIN-2015-04036
- 负责人:
- 金额:$ 1.6万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2017
- 资助国家:加拿大
- 起止时间:2017-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Articular cartilage and meniscus are essential for the normal mechanical function of the knee joint. These soft tissues are comprised of 65-80% fluid. Fluid flow is induced in these tissues by knee compressions during daily activities. Cartilage metabolism is also regulated by the synovial fluid, which brings nutrients to cartilage cells. Furthermore, fluid pressure can support over 50% of the knee load. Therefore, it is necessary to fully discover the mechanical and biological functions of fluid pressure and flow in cartilage and meniscus in order to understand normal knee mechanical functions. Currently, this information is very limited due to difficulties in both fluid pressure measurements inside the knee and fluid pressure predictions with an anatomically accurate model of the knee joint.
关节软骨和半月板对于膝关节的正常机械功能是必不可少的。这些软组织由65-80%的液体组成。在日常活动中,膝关节压迫会在这些组织中引起液体流动。软骨代谢也受到滑液的调节,滑液为软骨细胞提供营养。此外,流体压力可以支持超过50%的膝盖负荷。因此,有必要充分揭示软骨和半月板中流体压力和流动的力学和生物学功能,以了解正常的膝关节力学功能。目前,由于膝关节内的流体压力测量和利用膝关节的解剖学精确模型的流体压力预测两者的困难,该信息非常有限。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Li, LePing其他文献
Focal cartilage defect compromises fluid-pressure dependent load support in the knee joint
- DOI:
10.1002/cnm.2713 - 发表时间:
2015-06-01 - 期刊:
- 影响因子:2.1
- 作者:
Dabiri, Yaghoub;Li, LePing - 通讯作者:
Li, LePing
Strain-rate-dependent non-linear tensile properties of the superficial zone of articular cartilage
- DOI:
10.3109/03008207.2015.1066779 - 发表时间:
2015-11-02 - 期刊:
- 影响因子:2.9
- 作者:
Ahsanizadeh, Sahand;Li, LePing - 通讯作者:
Li, LePing
Li, LePing的其他文献
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{{ truncateString('Li, LePing', 18)}}的其他基金
Participant-specific and Generic Poromechanical Modelling of the Knee Joints
膝关节的参与者特定和通用孔隙力学建模
- 批准号:
RGPIN-2021-02869 - 财政年份:2022
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
Participant-specific and Generic Poromechanical Modelling of the Knee Joints
膝关节的参与者特定和通用孔隙力学建模
- 批准号:
RGPIN-2021-02869 - 财政年份:2021
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
Dynamic loading of pipelines during integrity management
完整性管理期间管道的动态加载
- 批准号:
514336-2017 - 财政年份:2020
- 资助金额:
$ 1.6万 - 项目类别:
Collaborative Research and Development Grants
Dynamic loading of pipelines during integrity management
完整性管理期间管道的动态加载
- 批准号:
514336-2017 - 财政年份:2018
- 资助金额:
$ 1.6万 - 项目类别:
Collaborative Research and Development Grants
Mechanics of Knee Joints - The Role of Fluid Pressure and Flow in Load Sharing and Cartilage Metabolism
膝关节力学 - 流体压力和流量在负荷分配和软骨代谢中的作用
- 批准号:
RGPIN-2015-04036 - 财政年份:2018
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
Consideration of the Interaction of Lateral and Torsional Vibrations to Improve the Safe Operation of Reciprocating Compressors**********
考虑横向和扭转振动的相互作用以提高往复式压缩机的安全运行************
- 批准号:
536315-2018 - 财政年份:2018
- 资助金额:
$ 1.6万 - 项目类别:
Engage Grants Program
Dynamic loading of pipelines during integrity management
完整性管理期间管道的动态加载
- 批准号:
514336-2017 - 财政年份:2017
- 资助金额:
$ 1.6万 - 项目类别:
Collaborative Research and Development Grants
Mechanics of Knee Joints - The Role of Fluid Pressure and Flow in Load Sharing and Cartilage Metabolism
膝关节力学 - 流体压力和流量在负荷分配和软骨代谢中的作用
- 批准号:
RGPIN-2015-04036 - 财政年份:2016
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
Novel Computational Nonlinear Analysis of Soil-Pipe Interaction under Large Displacement in Geo-Hazard Environment: a Preliminary Study
地质灾害环境下大位移土管相互作用的新型计算非线性分析:初步研究
- 批准号:
492480-2015 - 财政年份:2015
- 资助金额:
$ 1.6万 - 项目类别:
Engage Grants Program
Mechanics of Knee Joints - The Role of Fluid Pressure and Flow in Load Sharing and Cartilage Metabolism
膝关节力学 - 流体压力和流量在负荷分配和软骨代谢中的作用
- 批准号:
RGPIN-2015-04036 - 财政年份:2015
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
Knee能区宇宙线原初成份的研究
- 批准号:19665001
- 批准年份:1996
- 资助金额:8.0 万元
- 项目类别:地区科学基金项目
相似海外基金
Participant-specific and Generic Poromechanical Modelling of the Knee Joints
膝关节的参与者特定和通用孔隙力学建模
- 批准号:
RGPIN-2021-02869 - 财政年份:2022
- 资助金额:
$ 1.6万 - 项目类别:
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Multiscale simulation and measurement of knee joints biomechanics under physiological loading conditions
生理负荷条件下膝关节生物力学的多尺度模拟与测量
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RGPIN-2020-05087 - 财政年份:2022
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$ 1.6万 - 项目类别:
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Multiscale simulation and measurement of knee joints biomechanics under physiological loading conditions
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RGPIN-2020-05087 - 财政年份:2021
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$ 1.6万 - 项目类别:
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Participant-specific and Generic Poromechanical Modelling of the Knee Joints
膝关节的参与者特定和通用孔隙力学建模
- 批准号:
RGPIN-2021-02869 - 财政年份:2021
- 资助金额:
$ 1.6万 - 项目类别:
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Multiscale simulation and measurement of knee joints biomechanics under physiological loading conditions
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- 批准号:
RGPIN-2020-05087 - 财政年份:2020
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$ 1.6万 - 项目类别:
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Multiscale simulation and measurement of knee joints biomechanics under physiological loading conditions
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Discovery Launch Supplement
Getting Fit for Hip or Knee Replacement: The Fit Joints Randomized Controlled Trial of A Multimodal Intervention in Frail Patients with Osteoarthritis
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Operating Grants
Quantitative measurements of joint space width in knee joints in an American cohort of middle-aged and older adults compared with the Japanese population
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Mechanics of Knee Joints - The Role of Fluid Pressure and Flow in Load Sharing and Cartilage Metabolism
膝关节力学 - 流体压力和流量在负荷分配和软骨代谢中的作用
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RGPIN-2015-04036 - 财政年份:2019
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Experimental Study on Efficient Seismic Retrofitting using Ductile Knee Steel Braces for Timber Frame Joints
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