Mechanics of Knee Joints - The Role of Fluid Pressure and Flow in Load Sharing and Cartilage Metabolism

膝关节力学 - 流体压力和流量在负荷分配和软骨代谢中的作用

基本信息

  • 批准号:
    RGPIN-2015-04036
  • 负责人:
  • 金额:
    $ 1.6万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2019
  • 资助国家:
    加拿大
  • 起止时间:
    2019-01-01 至 2020-12-31
  • 项目状态:
    已结题

项目摘要

Articular cartilage and meniscus are essential for the normal mechanical function of the knee joint. These soft tissues are comprised of 65-80% fluid. Fluid flow is induced in these tissues by knee compressions during daily activities. Cartilage metabolism is also regulated by the synovial fluid, which brings nutrients to cartilage cells. Furthermore, fluid pressure can support over 50% of the knee load. Therefore, it is necessary to fully discover the mechanical and biological functions of fluid pressure and flow in cartilage and meniscus in order to understand normal knee mechanical functions. Currently, this information is very limited due to difficulties in both fluid pressure measurements inside the knee and fluid pressure predictions with an anatomically accurate model of the knee joint.***       We have recently initiated research into the modeling of cartilage and meniscus fluid pressure and flow. Our knee models are constructed based on magnetic resonance imaging obtained from human subjects. Comprehensive mathematical simulation is performed to elucidate the mechanical function of the knee regulated by the fluid pressure and flow. The proposed research will advance the understanding of mechanical functions of human knee joints to a level with more physiological relevance. The approaches and results will be validated through mechanical and biological tests on animal joints, and the results will be further explored in human knees through an innovative approach that takes full advantage of both computer modeling and high-resolution imaging on human subjects. We will (1) assess the load support mechanism of the human knee regulated by the fluid pressure, (2) discover the role of fluid pressure and flow in the cartilage metabolism of the pig knee, and (3) apply the validated approach to predict the knee mechanics of human standing and walking. These studies will fully use our recent progress in the modeling of the knee joint and existing state-of-the-art facilities at the University of Calgary to advance the contact mechanics of the joint. Expected outcomes from this research include further understanding of fundamental processes in knee joint mechanical functions and a comprehensive computer approach that can be used to predict subject-specific knee mechanics for individuals.***       Our validated approach and new results may be used in further developments in bioengineering. A well-established knee model can be further used in future studies to predict degenerated mechanical functions with aging. Knowledge of mechanically regulated cartilage metabolism, once it has been extended to human knee cartilage, may eventually be used to design exercise strategies to slow down the aging process in cartilage. A robust joint model could also be used in other applications, such as biomimetic design of mechanical and robotic systems. The research will attract promising young researchers to work in Canada.
关节软骨和半月板对于膝关节的正常机械功能是必不可少的。这些软组织由65-80%的液体组成。在日常活动中,膝关节压迫会在这些组织中引起液体流动。软骨代谢也受到滑液的调节,滑液为软骨细胞提供营养。此外,流体压力可以支持超过50%的膝盖负荷。因此,有必要充分揭示软骨和半月板中流体压力和流动的力学和生物学功能,以了解正常的膝关节力学功能。目前,由于膝关节内的流体压力测量和膝关节解剖学精确模型的流体压力预测都存在困难,因此这些信息非常有限。*       我们最近启动了对软骨和半月板流体压力和流量建模的研究。我们的膝关节模型是基于从人类受试者获得的磁共振成像构建的。进行了全面的数学模拟,以阐明膝关节的机械功能的流体压力和流量的调节。拟议的研究将推进人类膝关节的机械功能的理解,以更具有生理相关性的水平。这些方法和结果将通过对动物关节的机械和生物学测试进行验证,并将通过充分利用计算机建模和人类受试者高分辨率成像的创新方法在人类膝盖中进一步探索结果。我们将(1)评估由流体压力调节的人类膝关节的负载支撑机制,(2)发现流体压力和流量在猪膝关节软骨代谢中的作用,以及(3)应用经验证的方法来预测人类站立和行走的膝关节力学。这些研究将充分利用我们最近在膝关节建模方面的进展和卡尔加里大学现有的最先进的设施,以推进关节的接触力学。这项研究的预期成果包括进一步了解膝关节力学功能的基本过程,以及可用于预测个人特定学科膝关节力学的综合计算机方法。       我们验证的方法和新的结果可能用于生物工程的进一步发展。一个完善的膝关节模型可以进一步用于未来的研究,以预测退化的机械功能与老化。机械调节软骨代谢的知识,一旦扩展到人类膝关节软骨,最终可能用于设计运动策略,以减缓软骨的老化过程。鲁棒关节模型也可以用于其他应用,例如机械和机器人系统的仿生设计。这项研究将吸引有前途的年轻研究人员到加拿大工作。

项目成果

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Li, Leping其他文献

Gene set enrichment analysis for non-monotone association and multiple experimental categories.
  • DOI:
    10.1186/1471-2105-9-481
  • 发表时间:
    2008-11-14
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Lin, Rongheng;Dai, Shuangshuang;Irwin, Richard D.;Heinloth, Alexandra N.;Boorman, Gary A.;Li, Leping
  • 通讯作者:
    Li, Leping
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase suppresses insulin-like growth factor 1 receptor expression to inhibit cell adhesion and proliferation in gastric cancer.
  • DOI:
    10.1002/mco2.472
  • 发表时间:
    2024-02
  • 期刊:
  • 影响因子:
    9.9
  • 作者:
    Zhang, Zihao;Wang, Xu;Liu, Yuan;Wu, Hao;Zhu, Xingyu;Ye, Chunshui;Ren, Huicheng;Chong, Wei;Shang, Liang;Li, Leping
  • 通讯作者:
    Li, Leping
DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer.
  • DOI:
    10.1172/jci.insight.168161
  • 发表时间:
    2023-09-08
  • 期刊:
  • 影响因子:
    8
  • 作者:
    Li, Wenling;Nakano, Hideki;Fan, Wei;Li, Yuanyuan;Sil, Payel;Nakano, Keiko;Zhao, Fei;Karmaus, Peer W.;Grimm, Sara A.;Shi, Min;Xu, Xin;Mizuta, Ryushin;Kitamura, Daisuke;Wan, Yisong;Fessler, Michael B.;Cook, Donald N.;Shats, Igor;Li, Xiaoling;Li, Leping
  • 通讯作者:
    Li, Leping
PAVIS: a tool for Peak Annotation and Visualization
  • DOI:
    10.1093/bioinformatics/btt520
  • 发表时间:
    2013-12-01
  • 期刊:
  • 影响因子:
    5.8
  • 作者:
    Huang, Weichun;Loganantharaj, Rasiah;Li, Leping
  • 通讯作者:
    Li, Leping
Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network pharmacology and molecular docking.
  • DOI:
    10.21037/atm-22-4815
  • 发表时间:
    2022-10
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Zhang, Zihao;Chong, Wei;Xie, Xiaozhou;Liu, Yuan;Shang, Liang;Li, Leping
  • 通讯作者:
    Li, Leping

Li, Leping的其他文献

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{{ truncateString('Li, Leping', 18)}}的其他基金

Dynamic loading of pipelines during integrity management
完整性管理期间管道的动态加载
  • 批准号:
    514336-2017
  • 财政年份:
    2019
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Collaborative Research and Development Grants
Pathomechanics of human diarthrodial joints - associations with the structure of collagen network in articular cartilage
人类二节关节的病理力学 - 与关节软骨中胶原蛋白网络结构的关联
  • 批准号:
    356517-2009
  • 财政年份:
    2013
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Discovery Grants Program - Individual
Pathomechanics of human diarthrodial joints - associations with the structure of collagen network in articular cartilage
人类二节关节的病理力学 - 与关节软骨中胶原蛋白网络结构的关联
  • 批准号:
    356517-2009
  • 财政年份:
    2012
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Discovery Grants Program - Individual
Pathomechanics of human diarthrodial joints - associations with the structure of collagen network in articular cartilage
人类二节关节的病理力学 - 与关节软骨中胶原蛋白网络结构的关联
  • 批准号:
    356517-2009
  • 财政年份:
    2011
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Discovery Grants Program - Individual
Pathomechanics of human diarthrodial joints - associations with the structure of collagen network in articular cartilage
人类二节关节的病理力学 - 与关节软骨中胶原蛋白网络结构的关联
  • 批准号:
    356517-2009
  • 财政年份:
    2010
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Discovery Grants Program - Individual
Pathomechanics of human diarthrodial joints - associations with the structure of collagen network in articular cartilage
人类二节关节的病理力学 - 与关节软骨中胶原蛋白网络结构的关联
  • 批准号:
    356517-2009
  • 财政年份:
    2009
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Discovery Grants Program - Individual
Modeling of cartilage for the design of an arthroscopic probe for arthritis diagnosis
软骨建模用于设计用于关节炎诊断的关节镜探针
  • 批准号:
    227243-1999
  • 财政年份:
    2002
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Industrial Research Fellowships
Modeling of cartilage for the design of an arthroscopic probe for arthritis diagnosis
软骨建模用于设计用于关节炎诊断的关节镜探针
  • 批准号:
    227243-1999
  • 财政年份:
    2001
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Industrial Research Fellowships
Modeling of cartilage for the design of an arthroscopic probe for arthritis diagnosis
软骨建模用于设计用于关节炎诊断的关节镜探针
  • 批准号:
    227243-1999
  • 财政年份:
    2000
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Industrial Research Fellowships

相似国自然基金

Knee能区宇宙线原初成份的研究
  • 批准号:
    19665001
  • 批准年份:
    1996
  • 资助金额:
    8.0 万元
  • 项目类别:
    地区科学基金项目

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Participant-specific and Generic Poromechanical Modelling of the Knee Joints
膝关节的参与者特定和通用孔隙力学建模
  • 批准号:
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  • 财政年份:
    2022
  • 资助金额:
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Multiscale simulation and measurement of knee joints biomechanics under physiological loading conditions
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  • 批准号:
    RGPIN-2020-05087
  • 财政年份:
    2022
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Multiscale simulation and measurement of knee joints biomechanics under physiological loading conditions
生理负荷条件下膝关节生物力学的多尺度模拟与测量
  • 批准号:
    RGPIN-2020-05087
  • 财政年份:
    2021
  • 资助金额:
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Participant-specific and Generic Poromechanical Modelling of the Knee Joints
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  • 批准号:
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  • 财政年份:
    2021
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Multiscale simulation and measurement of knee joints biomechanics under physiological loading conditions
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  • 批准号:
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  • 财政年份:
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  • 批准号:
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  • 财政年份:
    2020
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Quantitative measurements of joint space width in knee joints in an American cohort of middle-aged and older adults compared with the Japanese population
美国中老年人群与日本人群相比膝关节间隙宽度的定量测量
  • 批准号:
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    434345
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    2020
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Experimental Study on Efficient Seismic Retrofitting using Ductile Knee Steel Braces for Timber Frame Joints
木框架节点延性膝钢支撑高效抗震改造试验研究
  • 批准号:
    19K15081
  • 财政年份:
    2019
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    $ 1.6万
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    Grant-in-Aid for Early-Career Scientists
Basic validation of the efficacy of insoluble hyaluronic acid for the development of new prophylactic agents for postoperative contracture of knee joints
不溶性透明质酸开发膝关节术后挛缩新型预防剂功效的基础验证
  • 批准号:
    19K06411
  • 财政年份:
    2019
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    $ 1.6万
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    Grant-in-Aid for Scientific Research (C)
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