Development of diagnostic and predictive computational mechanics methods for cardiovascular system

心血管系统的主要功能是运输、控制和维持全身的血液流动。血流动力学异常极大地改变了这一平静的图景，导致疾病的发生和发展。心血管疾病是全球主要的死亡原因。在加拿大，每四例死亡中就有一例死于心血管疾病。血流定量对于准确和早期诊断有很大帮助，但我们仍然缺乏对许多心血管疾病的正确诊断方法。此外，由于大多数干预措施旨在恢复健康状况，因此预测特定干预措施后的血流动力学和生物力学的能力可能对挽救生命产生重大影响。尽管医学成像技术取得了显著进步，但预测方法仍然很少。

The main functions of the cardiovascular system are to transport, control and maintain blood flow in the entire body. Abnormal hemodynamics greatly alters this tranquil picture, leading to initiation and progression of disease. Cardiovascular disease is the leading cause of death globally. In Canada, one in every four deaths is from cardiovascular disease. Flow quantification can be greatly useful for accurate and early diagnosis but we still lack proper diagnostic methods for many cardiovascular diseases. Furthermore, as most interventions intend to recover the healthy condition, the ability to predict hemodynamics and biomechanics following a particular intervention can have significant impacts on saving lives. Despite remarkable advances in medical imaging, predictive methods remain rare.