Preventing Tumour Onset in Li-Fraumeni Syndrome by Inhibiting the Mechanistic Target of Rapamycin (mTOR)-Regulated Senescence-Associated Secretory Phenotype
Preventing Tumour Onset in Li-Fraumeni Syndrome by Inhibiting the Mechanistic Target of Rapamycin (mTOR)-Regulated Senescence-Associated Secretory Phenotype
通过抑制雷帕霉素 (mTOR) 调节的衰老相关分泌表型的机制靶点来预防 Li-Fraumeni 综合征的肿瘤发生
批准号：
386340
负责人：
Giovino Camilla M
金额：
$1.27万
依托单位：
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-12-01 至 2018-12-01
中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Individuals with Li-Fraumeni Syndrome (LFS) are prone to developing early-onset malignancies because the TP53 tumour suppressor gene is mutated in all of their cells. p53 promotes DNA repair, cell cycle arrest, and death of pre-malignant cells, making m
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
海外基金
