Zebrafish tp53 Mutants Recapitulate Li-Fraumeni Syndrome Phenotypes and Provide a Preclinical Platform for Evaluating Tumor Preventive Compounds
Zebrafish tp53 Mutants Recapitulate Li-Fraumeni Syndrome Phenotypes and Provide a Preclinical Platform for Evaluating Tumor Preventive Compounds
批准号:
477539
负责人:
Kobar Kimberly
金额:
$7.65万
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-10-01 至 2025-10-01
中文摘要
Li-Fraumeni综合征(LFS)是一种遗传性疾病,通常由身体每个细胞中TP 53基因的突变引起。这些突变大大增加了患癌症的风险,通常在儿童时期。p53是TP 53基因的蛋白产物,
英文摘要
Li-Fraumeni Syndrome (LFS) is an inherited disorder typically caused by mutations in the TP53 gene in every cell of the body. These mutations greatly increase the risk of developing cancer, usually during childhood. p53, the protein product of the TP53 ge
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