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Zebrafish tp53 Mutants Recapitulate Li-Fraumeni Syndrome Phenotypes and Provide a Preclinical Platform for Evaluating Tumor Preventive Compounds

Zebrafish tp53 Mutants Recapitulate Li-Fraumeni Syndrome Phenotypes and Provide a Preclinical Platform for Evaluating Tumor Preventive Compounds
斑马鱼 tp53 突变体重现了 Li-Fraumeni 综合征表型,并为评估肿瘤预防化合物提供了临床前平台
批准号:
477539
负责人:
Kobar Kimberly
金额:
$7.65万
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-10-01 至 2025-10-01

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英文摘要
Li-Fraumeni Syndrome (LFS) is an inherited disorder typically caused by mutations in the TP53 gene in every cell of the body. These mutations greatly increase the risk of developing cancer, usually during childhood. p53, the protein product of the TP53 ge
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