Next-generation of Transforming Growth Factor ß inhibitors
下一代转化生长因子 – 抑制剂
基本信息
- 批准号:520583-2017
- 负责人:
- 金额:$ 1.82万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Engage Grants Program
- 财政年份:2017
- 资助国家:加拿大
- 起止时间:2017-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Transforming growth factor beta (TGF-ß) is a pleiotropic cytokine with essential roles in normal embryonicdevelopment and tissue homeostasis. The role of excessive TGF-ß action in fibrosis is well documented.Therefore, it is of interest to develop drugs that block TGF-ß signaling for therapeutic benefit. This therapeuticniche is now being explored by Formation Biologics, a Canadian company focusing on the development ofTGF-ß inhibitors. Formation has a successful drug development record with one product in phase I clinicaltrials, and a second in IND-enabling development. To continue its efforts in the development of specific TGF-ßinhibitors (i.e. specific to each isoform within the TGF-ß superfamily), Formation Biologics is now interestedin exploring promising alternatives to antibody-based therapeutics. The proposed research thus focuses onharnessing the TGF-ß-neutralizing potential of TGF-ß receptor extracellular domains to develop potent TGF-ßantagonists. More specifically, the proposal is to physically combine various receptor extracellular domains toimprove their TGF-ß binding and sequestration efficiency while taking advantage of their binding specificity. Ifperformed with a classical experimental approach (i.e., the design of chimeric proteins corresponding to thefusion of two distinct receptors, their purification and related assays), such a study would be extremelytime-consuming if one considers the number of TGF-ß isoforms, the number of receptors they bind to, as wellas the number of resulting receptor combinations. Using a unique molecular adaptor strategy emanating fromprevious work performed in De Crescenzo's lab, the inhibition of TGF-ß signaling by different TGF-ß receptorcombinations will be tested more rapidly by setting an innovative mix-and-match strategy. The expectedoutcome is a competitive and novel strategy to inhibit TGF-ß signaling. Successful completion of this projectwill provide Formation Biologics with a new therapeutic avenue to inhibit TGF-ß signaling, hence promotingthe development of new drugs, and thus directly benefiting the Canadian patient population and economy.
转化生长因子β(transforminggrowthfactorbeta,TGF-β)是一种多效性细胞因子,在正常胚胎发育和组织稳态中起重要作用.过度的TGF-β作用在纤维化中的作用是有据可查的,因此,开发阻断TGF-β信号传导的药物以获得治疗益处是有意义的。这一治疗领域目前正由FormationBiologics公司进行探索,该公司是一家专注于开发TGF-β抑制剂的加拿大公司。Formation有一个成功的药物开发记录,一个产品在I期临床试验中,另一个在IND开发中。为了继续开发特异性TGF-β抑制剂(即对TGF-β超家族中的每种亚型都具有特异性),Formation Biologics现在致力于探索基于抗体的治疗方法的有前景的替代品。因此,拟议的研究集中在利用TGF-β受体胞外结构域的TGF-β中和潜力来开发有效的TGF-β拮抗剂。更具体地说,该建议是物理上联合收割机结合各种受体胞外结构域,以提高它们的TGF-β结合和螯合效率,同时利用它们的结合特异性.如果用经典的实验方法(即,设计与两种不同受体的融合相对应的嵌合蛋白,它们的纯化和相关的测定),如果考虑到TGF-β同种型的数量、它们结合的受体的数量以及产生的受体组合的数量,这样的研究将是非常耗时的。使用De Crescenzo实验室先前工作中产生的独特分子适配器策略,通过设置创新的混合匹配策略,将更快地测试不同TGF-β受体组合对TGF-β信号传导的抑制。预期的结果是一个有竞争力的和新的策略来抑制TGF-β信号转导。该项目的成功完成为Formation Biologics提供了抑制TGF-β信号传导的新治疗途径,从而促进新药的开发,从而直接造福加拿大患者群体和经济。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
DeCrescenzo, Gregory其他文献
DeCrescenzo, Gregory的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('DeCrescenzo, Gregory', 18)}}的其他基金
Coiled-coil assisted control of antibody quality, delivery and binding
卷曲螺旋辅助控制抗体质量、递送和结合
- 批准号:
RGPIN-2020-07039 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Process Engineering of Emerging Nano-Medicines (PrEEmiuM)
新兴纳米药物的工艺工程(PrEEmiuM)
- 批准号:
511957-2018 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Training Experience
Coiled-coil assisted control of antibody quality, delivery and binding
卷曲螺旋辅助控制抗体质量、递送和结合
- 批准号:
RGPIN-2020-07039 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Coiled-coil assisted control of antibody quality, delivery and binding
卷曲螺旋辅助控制抗体质量、递送和结合
- 批准号:
RGPIN-2020-07039 - 财政年份:2020
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Process Engineering of Emerging Nano-Medicines (PrEEmiuM)
新兴纳米药物的工艺工程(PrEEmiuM)
- 批准号:
511957-2018 - 财政年份:2020
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Training Experience
Process Engineering of Emerging Nano-Medicines (PrEEmiuM)
新兴纳米药物的工艺工程(PrEEmiuM)
- 批准号:
511957-2018 - 财政年份:2019
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Training Experience
Decoration and Dimerization of Chimeric Proteins Mediated by Coiled-Coil Interactions
卷曲螺旋相互作用介导的嵌合蛋白的修饰和二聚化
- 批准号:
537306-2018 - 财政年份:2019
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Development Grants
Surface Bioconjugation for Regenerative Medicine and Biosensing Applications
用于再生医学和生物传感应用的表面生物共轭
- 批准号:
RGPIN-2015-04960 - 财政年份:2019
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Surface Bioconjugation for Regenerative Medicine and Biosensing Applications
用于再生医学和生物传感应用的表面生物共轭
- 批准号:
RGPIN-2015-04960 - 财政年份:2018
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Process Engineering of Emerging Nano-Medicines (PrEEmiuM)
新兴纳米药物的工艺工程(PrEEmiuM)
- 批准号:
511957-2018 - 财政年份:2018
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Training Experience
相似国自然基金
细胞周期蛋白依赖性激酶Cdk1介导卵母细胞第一极体重吸收致三倍体发生的调控机制研究
- 批准号:82371660
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
Next Generation Majorana Nanowire Hybrids
- 批准号:
- 批准年份:2020
- 资助金额:20 万元
- 项目类别:
二次谐波非线性光学显微成像用于前列腺癌的诊断及药物疗效初探
- 批准号:30470495
- 批准年份:2004
- 资助金额:20.0 万元
- 项目类别:面上项目
相似海外基金
Transforming pastefill delivery system for next-generation mining industry
改造下一代采矿业的膏体填充输送系统
- 批准号:
LP220100131 - 财政年份:2023
- 资助金额:
$ 1.82万 - 项目类别:
Linkage Projects
Achieving Maternal Equity and Transforming Health through Implementation Science and Training (AMETHIST@Penn)
通过实施科学和培训实现孕产妇公平并改变健康状况 (AMETHIST@Penn)
- 批准号:
10748593 - 财政年份:2023
- 资助金额:
$ 1.82万 - 项目类别:
Transforming Analytical Learning in the Era of Big Data: A Summer Institute in Biostatistics and Data Science
大数据时代的分析学习变革:生物统计学和数据科学暑期学院
- 批准号:
10366563 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Transforming Analytical Learning in the Era of Big Data: A Summer Institute in Biostatistics and Data Science
大数据时代的分析学习变革:生物统计学和数据科学暑期学院
- 批准号:
10549365 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
FW-HTF-P: Transforming 911 dispatchers into Next-Generation 911 analysts: Sustainable innovation for training, workflow, and technology resources for NG911 emergency communications
FW-HTF-P:将 911 调度员转变为下一代 911 分析师:NG911 应急通信的培训、工作流程和技术资源的可持续创新
- 批准号:
2129126 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Standard Grant
Transforming Analytical Learning in the Era of Big Data
大数据时代的分析学习变革
- 批准号:
9888408 - 财政年份:2019
- 资助金额:
$ 1.82万 - 项目类别:
Transforming Research and Clinical Knowledge in Traumatic Brain Injury
改变创伤性脑损伤的研究和临床知识
- 批准号:
9430640 - 财政年份:2017
- 资助金额:
$ 1.82万 - 项目类别:
Training and Teaching for Transforming Big Data to Knowledge
将大数据转化为知识的培训和教学
- 批准号:
9564195 - 财政年份:2017
- 资助金额:
$ 1.82万 - 项目类别:
Next-Generation Sequencing Center for GHOSTing Hepatitis C Virus: Transforming Community Based Molecular Surveillance and Outbreak Investigation
丙型肝炎病毒重影的下一代测序中心:改变基于社区的分子监测和疫情调查
- 批准号:
10241239 - 财政年份:2017
- 资助金额:
$ 1.82万 - 项目类别: