Polymer conjugation to the Feldan Shuttle to reduce blood protein adsorption and interaction with cell membranes

聚合物与 Feldan Shuttle 结合，减少血液蛋白吸附以及与细胞膜的相互作用

• 批准号: 521307-2017
• 负责人: Gauthier, Marc
• 金额: $ 1.82万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=639466
• 关键词: Polymer; conjugation; Feldan; Shuttle; reduce

For a medication to be effective, it must be able to reach its target. One of the greatest challenges for manydrugs is that their targets lie inside cells. Indeed, cells are surrounded by a membrane that keeps manymolecules out - including drugs. Even the most powerful drug will be ineffective if it cannot reach its target.Feldan Therapeutics Inc. has developed a technology, termed the Feldan shuttle, which facilitates the transferof several types of drugs into cells. They now face a technological challenge, associated with the stability of theShuttle in blood, that they cannot resolve themselves. As such, Feldan Therapeutics Inc. has approached ProfMarc A Gauthier of the INRS to investigate structural alterations to the Shuttle and the influence of thesemodifications on: 1) the physical nature of complexes formed with therapeutic cargo, and 2) their interactionwith blood proteins.

要使药物有效，它必须能够达到其目标。许多药物面临的最大挑战之一是它们的靶点位于细胞内。事实上，细胞被一层膜所包围，这层膜将许多分子（包括药物）拒之门外。即使是最强大的药物，如果不能达到目标，也是无效的。已经开发了一种技术，称为费尔丹穿梭机，它有助于将几种类型的药物转移到细胞中。他们现在面临着一个技术上的挑战，与穿梭机在血液中的稳定性有关，他们无法自己解决。因此，Feldan Therapeutics Inc.已经联系了INRS的Marc A Gauthier教授，研究航天飞机的结构改变以及这些改变对以下方面的影响：1）与治疗货物形成的复合物的物理性质，2）它们与血液蛋白的相互作用。