Polymer conjugation to the Feldan Shuttle to reduce blood protein adsorption and interaction with cell membranes

为了使药物有效，它必须能够达到它的目标。许多药物面临的最大挑战之一是它们的靶点在细胞内。事实上，细胞被一层膜所包围，这层膜将包括药物在内的许多分子拒之门外。即使是最强大的药物，如果不能达到目标也会失效。费尔丹治疗公司开发了一种名为费尔丹穿梭的技术，可以促进几种药物进入细胞。他们现在面临着一个技术挑战，与血液中航天飞机的稳定性有关，这是他们自己无法解决的。因此，Feldan Therapeutics Inc.已经联系了INRS的marc A Gauthier教授，研究航天飞机的结构变化以及这些修饰对以下方面的影响：1)与治疗货物形成的复合物的物理性质，以及2)它们与血液蛋白的相互作用。

For a medication to be effective, it must be able to reach its target. One of the greatest challenges for manydrugs is that their targets lie inside cells. Indeed, cells are surrounded by a membrane that keeps manymolecules out - including drugs. Even the most powerful drug will be ineffective if it cannot reach its target.Feldan Therapeutics Inc. has developed a technology, termed the Feldan shuttle, which facilitates the transferof several types of drugs into cells. They now face a technological challenge, associated with the stability of theShuttle in blood, that they cannot resolve themselves. As such, Feldan Therapeutics Inc. has approached ProfMarc A Gauthier of the INRS to investigate structural alterations to the Shuttle and the influence of thesemodifications on: 1) the physical nature of complexes formed with therapeutic cargo, and 2) their interactionwith blood proteins.