Addressing an immediate manufacturing need of the therapeutic antibody industry - reduce viscosity to reduce cost.

涉及人类单抗的治疗策略正变得越来越普遍。然而，单抗的溶液具有异常高的粘度，这是由于它们自组装成簇造成的。这是行业扩大制造能力的瓶颈，并强加了需要医疗保健专业人员管理单抗的产品格式，这两者都显著增加了成本。目前，单抗疗法的成本每年可达数千美元，这是令人望而却步的--无论它们治疗疾病的效果如何。因此，迫切需要解决高粘度带来的制造挑战。有了初步数据，这一战略项目提出了前所未有的概念来降低单抗溶液的粘度，这将彻底改变治疗性单抗行业。更具体地说，我们将与Axis Photonique Inc.合作，探索使用激光来降低单抗溶液粘度，这将有助于生产。此外，我们还将与Altus配方公司合作，开发可以降低单抗溶液粘度的添加剂，这将使它们能够使用注射器注射(目前这是很难实现的)。该项目是在这一领域培训HQP的绝佳机会，具有重要的社会和经济意义。该项目的成果将构成重大技术进步，将降低单抗及其相应疗法的成本。它最终将使患病的加拿大人更容易获得更好的药物，并改变治疗策略，导致更好的患者结果。

Therapeutic strategies involving human monoclonal antibodies (mAbs) are becoming increasingly prevalent. However, solutions of mAbs possess unusually high viscosity, caused by their self-assembly into clusters. This is a bottleneck for industry's ability to scale-up manufacturing and imposes product formats that require healthcare professionals to administer the mAb, both of which significantly increase cost. At present, the cost of mAb therapies can reach several thousands of dollars per year, which is prohibitive to their use - irrespective of how well they treat disease. There is thus an immediate and urgent need to address the manufacturing challenges posed by high viscosity. With preliminary data in hand, this Strategic project proposes unprecedented concepts to reduce mAb solution viscosity, which will revolutionize the therapeutic mAb industry. More specifically, with Axis Photonique Inc., we will explore the use of lasers to reduce mAb solution viscosity, which will facilitate production. In addition, with Altus Formulation Inc., we will develop additives that can reduce mAb solution viscosity, which will enable their injection using syringes (currently this is very difficult to achieve). This project represents an excellent opportunity to train HQP in this area, which is of great social and economic importance. The outputs of this project will constitute major technological advances that will reduce the cost of monoclonal antibodies and their corresponding therapies. It will ultimately make better drugs more accessible to sick Canadians and change therapeutic strategies, leading to better patient outcomes.**