Polymer conjugation to the Feldan Shuttle and its cargo to increase bioavailability in circulation

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For a medication to be effective, it must be able to reach its target. One of the greatest challenges for many**drugs is that their targets lie inside cells. Indeed, cells are surrounded by a membrane that keeps many**molecules out - including drugs. Even the most powerful drug will be ineffective if it cannot reach its target.**Feldan Therapeutics Inc. has developed a technology, termed the Feldan Shuttle, which facilitates the transfer**of several types of drugs into cells. They now face a technological challenge, associated with the ability of the**Shuttle to be effective in the context of intravenous injections, that they cannot resolve themselves. As such,**Feldan Therapeutics Inc. has approached Prof Marc A Gauthier of the INRS to investigate structural alterations**to the Shuttle and its cargo to increase their bioavailability in circulation.