Polymer conjugation to the Feldan Shuttle and its cargo to increase bioavailability in circulation

聚合物与 Feldan Shuttle 及其货物的结合可提高循环中的生物利用度

• 批准号: 530982-2018
• 负责人: Gauthier, Marc
• 金额: $ 0.91万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=651611
• 关键词: Polymer; conjugation; Feldan; Shuttle; its

For a medication to be effective, it must be able to reach its target. One of the greatest challenges for many**drugs is that their targets lie inside cells. Indeed, cells are surrounded by a membrane that keeps many**molecules out - including drugs. Even the most powerful drug will be ineffective if it cannot reach its target.**Feldan Therapeutics Inc. has developed a technology, termed the Feldan Shuttle, which facilitates the transfer**of several types of drugs into cells. They now face a technological challenge, associated with the ability of the**Shuttle to be effective in the context of intravenous injections, that they cannot resolve themselves. As such,**Feldan Therapeutics Inc. has approached Prof Marc A Gauthier of the INRS to investigate structural alterations**to the Shuttle and its cargo to increase their bioavailability in circulation.

要使药物有效，它必须能够达到其目标。许多药物面临的最大挑战之一是它们的靶点位于细胞内。事实上，细胞被一层膜所包围，这层膜将许多 ** 分子（包括药物）拒之门外。即使是最强大的药物，如果不能达到目标，也会无效。费尔丹治疗公司已经开发了一种技术，称为费尔丹穿梭机，它有助于将几种类型的药物转移到细胞中。他们现在面临着一个技术挑战，与 ** 航天飞机在静脉注射方面的有效能力有关，他们无法自己解决。因此，**Feldan Therapeutics Inc.已经与INRS的Marc A Gauthier教授接触，研究航天飞机及其货物的结构改变 **，以增加其在循环中的生物利用度。