Polymer conjugation to the Feldan Shuttle and its cargo to increase bioavailability in circulation

为了使药物有效，它必须能够达到它的目标。许多**药物面临的最大挑战之一是它们的靶点在细胞内。事实上，细胞被一层膜所包围，这层膜将包括药物在内的许多分子拒之门外。即使是最强大的药物，如果不能达到目标也会失效。Feldan Therapeutics公司开发了一种名为Feldan Shuttle的技术，可以促进多种药物进入细胞。他们现在面临着一项技术挑战，这与航天飞机在静脉注射中是否有效有关，而他们自己无法解决这个问题。因此，Feldan Therapeutics Inc.已与INRS的Marc A Gauthier教授联系，研究对航天飞机及其货物进行结构改变，以提高其在循环中的生物利用度。

For a medication to be effective, it must be able to reach its target. One of the greatest challenges for many**drugs is that their targets lie inside cells. Indeed, cells are surrounded by a membrane that keeps many**molecules out - including drugs. Even the most powerful drug will be ineffective if it cannot reach its target.**Feldan Therapeutics Inc. has developed a technology, termed the Feldan Shuttle, which facilitates the transfer**of several types of drugs into cells. They now face a technological challenge, associated with the ability of the**Shuttle to be effective in the context of intravenous injections, that they cannot resolve themselves. As such,**Feldan Therapeutics Inc. has approached Prof Marc A Gauthier of the INRS to investigate structural alterations**to the Shuttle and its cargo to increase their bioavailability in circulation.