Endogenous Fluorescence Imaging of Clinically Important Bacteria on Surfaces

表面上临床重要细菌的内源荧光成像

• 批准号: 520219-2017
• 负责人: Foucher, Daniel
• 金额: $ 1.82万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=639936
• 关键词: Endogenous; Fluorescence; Imaging; Clinically; Important

The proposed project is to establish feasibility of fluorescence imaging of bacterial load in vivo and toinvestigate the possibility of quantification of bacteria present. The main research challenges are (1) theidentification of the optimal excitation with potential for assessment of bacterial load in realistic settings, and(2) demonstrate the usefulness of the fluorescence imaging system for bacterial load visualization in anon-invasive manner. To this end endogenous fluorescence imaging has the capacity to assess bacterial load forclinically-relevant bacteria. Our group has significant expertise in the area of microbial surfaces and theutilization of fluorescence spectroscopy to study those systems. This collaboration would help Oxilightdeveloping fluorescence imaging modality complementary to its multispectral imaging device.

该项目旨在建立体内细菌负荷荧光成像的可行性，并研究定量细菌存在的可能性。主要的研究挑战是（1）识别具有在现实环境中评估细菌负荷潜力的最佳激发，以及（2）证明荧光成像系统以非侵入性方式用于细菌负荷可视化的有用性。为此，内源性荧光成像具有评估临床相关细菌的细菌负荷的能力。我们的团队在微生物表面和利用荧光光谱学研究这些系统方面具有重要的专业知识。这项合作将有助于Oxilight开发与其多光谱成像设备互补的荧光成像模式。