Analysis of Heat Loads During Production of Radioactive Medical Isotopes

放射性医用同位素生产过程中的热负荷分析

基本信息

  • 批准号:
    509229-2017
  • 负责人:
  • 金额:
    $ 1.82万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Engage Grants Program
  • 财政年份:
    2017
  • 资助国家:
    加拿大
  • 起止时间:
    2017-01-01 至 2018-12-31
  • 项目状态:
    已结题

项目摘要

Over the last 40 years the improvement in medical isotopes has allowed for the effective treatments of manytypes of cancer through the continuous development of both new isotopes and new delivery mechanisms. ABKBiomedical is developing a suite of imageable embolic microspheres for the treatment of some cancers. One oftheir products is a new and unique method of isotope delivery directly to the affected cells involves the preciseand localized injection of radioactive materials within micro-sized spheres to a cancerous region. Theproduction process involves taking non-radioactive spheres containing suitable target isotopes and packingthem into a relatively small volume and then activating them in a nuclear reactor. Due to neutron and gammaradiation interaction with these spheres each undergoes volumetric heating from the energy deposited in theseinteractions. Depending on the materials, sphere geometry, irradiation time and neutron/gamma fields in thereactor, the heat deposited in the spheres may be significant, and possibly exceed the heat removal capacity ofthe assembly. In such cases the spheres will melt resulting in a loss of the batch of isotopes being irradiated.ABK Biomedical wishes to develop the irradiation protocols such as to maximize their production output. Thisproject will develop and tests new tools and methods for the simulation of such embolic spheres and attempt todevelop more robust irradiation methods where production can be maximized.
在过去的40年里,通过不断开发新的同位素和新的输送机制,医用同位素的改进使多种癌症的有效治疗成为可能。ABKBiomedical正在开发一套可想象的栓塞微球,用于治疗某些癌症。他们的产品之一是一种新的和独特的方法,将同位素直接输送到受影响的细胞,包括将放射性物质精确和局部地注射到微小的球体内的癌变区域。生产过程包括将含有合适目标同位素的非放射性球体包装成相对较小的体积,然后在核反应堆中激活它们。由于中子和伽玛辐射与这些球体的相互作用,每个球体都经历了这些相互作用中沉积的能量的体积加热。根据材料、球体几何形状、辐照时间和反应堆中的中子/伽马场,沉积在球体上的热量可能是显著的,并且可能超过组件的热量去除能力。在这种情况下,球体将熔化,导致被辐照的那批同位素的损失。ABK生物医学公司希望制定辐照方案,以最大限度地提高其产量。该项目将开发和测试用于模拟此类栓塞球体的新工具和方法,并尝试开发更强大的辐照方法,以最大限度地提高产量。

项目成果

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Novog, David其他文献

Novog, David的其他文献

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{{ truncateString('Novog, David', 18)}}的其他基金

Development of Novel-Fuels with Enhanced Safety Characteristics for Use in Nuclear Power Generation
开发用于核能发电的具有增强安全特性的新型燃料
  • 批准号:
    RGPIN-2017-05607
  • 财政年份:
    2022
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Discovery Grants Program - Individual
Nuclear Safety Uncertainty Development Project
核安全不确定性开发项目
  • 批准号:
    567028-2021
  • 财政年份:
    2021
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Alliance Grants
Development of a Fast Neutron Computed Tomography System for Non-Invasive Testing
用于非侵入性测试的快中子计算机断层扫描系统的开发
  • 批准号:
    532146-2018
  • 财政年份:
    2021
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Collaborative Research and Development Grants
Development of Novel-Fuels with Enhanced Safety Characteristics for Use in Nuclear Power Generation
开发用于核能发电的具有增强安全特性的新型燃料
  • 批准号:
    RGPIN-2017-05607
  • 财政年份:
    2021
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Discovery Grants Program - Individual
Small Modular Advanced Reactor Training (SMART) CREATE
小型模块化先进反应堆训练(SMART)CREATE
  • 批准号:
    528176-2019
  • 财政年份:
    2021
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Collaborative Research and Training Experience
Development of a Fast Neutron Computed Tomography System for Non-Invasive Testing
用于非侵入性测试的快中子计算机断层扫描系统的开发
  • 批准号:
    532146-2018
  • 财政年份:
    2020
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Collaborative Research and Development Grants
Development of Novel-Fuels with Enhanced Safety Characteristics for Use in Nuclear Power Generation
开发用于核能发电的具有增强安全特性的新型燃料
  • 批准号:
    RGPIN-2017-05607
  • 财政年份:
    2020
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Discovery Grants Program - Individual
Risk Informed Safety Margin Characterization for Nuclear Reactors Using Dynamic Risk Assesment Methods
使用动态风险评估方法对核反应堆进行风险知情安全裕度表征
  • 批准号:
    522366-2017
  • 财政年份:
    2020
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Collaborative Research and Development Grants
Small Modular Advanced Reactor Training (SMART) CREATE
小型模块化先进反应堆训练(SMART)CREATE
  • 批准号:
    528176-2019
  • 财政年份:
    2020
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Collaborative Research and Training Experience
Risk Informed Safety Margin Characterization for Nuclear Reactors Using Dynamic Risk Assesment Methods
使用动态风险评估方法对核反应堆进行风险知情安全裕度表征
  • 批准号:
    522366-2017
  • 财政年份:
    2019
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Collaborative Research and Development Grants

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  • 批准号:
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