Development and Characterization of an implantable system-on-a-chip for long-term ambulatory EEG monitoring

来自大脑的电信号的测量和记录被称为脑电(EEG)，通常用于诊断和治疗许多神经系统疾病，包括癫痫、睡眠障碍、脑损伤等。在目前的脑电仪器中，患者必须通过有线电极连接到记录硬件上，或者佩戴笨重的耳机来存储和/或传输脑电数据，同时为系统供电。在任何一种情况下，当患者进行正常的日常和日常活动时，都不可能在较长的时间内获得高质量的EEG数据。由于应用于头皮的电极只能在有限的时间内保持舒适、低阻抗的接触，长期脑电记录变得更加复杂。因此，医生通常根据有限和不完整的脑电信息做出临床决策，或者在许多神经疾病的临床工作流程中完全没有任何脑电信息。拟议的项目将通过设计用于脑电数据采集、存储和传输的微型化电子设备来推动植入式和可穿戴脑电采集系统的发展。与由高度生物兼容和耐用的有机电子材料制成的专用电极相结合，整体解决方案将克服当前仪器的局限性，允许长期脑电的广泛使用，从而更好地诊断和管理神经疾病，并改善患者的预后。

The measurement and recording of electrical signals from the brain is known as electroencephalography (EEG)and is commonly used as part of the diagnosis and treatment planning for numerous neurological conditionsincluding epilepsy, sleep disorders, brain injury, and others. With current EEG instrumentation, the patientmust either be tethered to the recording hardware by wired electrodes, or wear a bulky headset to store and/ortransmit the EEG data while powering the system. In either case, it is not possible to obtain high quality EEGdata over long periods of time while the patient goes about their normal routine and daily activities. Long-termEEG recording is further complicated by the fact that electrodes applied to the scalp only maintain comfortable,low-impedance contact for limited periods of time. As a result, physicians commonly make clinical decisionsbased on limited and incomplete EEG information or, in clinical workflows for many neurological conditions,without any EEG information at all.The proposed project will advance the development of implantable and wearable EEG acquisition systems bydesigning miniaturized electronics for EEG data collection, storage, and transmission. Combined withspecialized electrodes made from highly biocompatible and durable organic electronic materials, the overallsolution will overcome the limitations of current instrumentation and allow for widespread use of long-termEEG, resulting in better diagnosis and management of neurological conditions and leading to improved patientoutcomes.