Development and Characterization of an implantable system-on-a-chip for long-term ambulatory EEG monitoring

用于长期动态脑电图监测的植入式芯片系统的开发和表征

• 批准号: 521961-2017
• 负责人: Kassiri, Hossein
• 金额: $ 1.82万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=640050
• 关键词: Development; Characterization; implantable; system; chip

The measurement and recording of electrical signals from the brain is known as electroencephalography (EEG)and is commonly used as part of the diagnosis and treatment planning for numerous neurological conditionsincluding epilepsy, sleep disorders, brain injury, and others. With current EEG instrumentation, the patientmust either be tethered to the recording hardware by wired electrodes, or wear a bulky headset to store and/ortransmit the EEG data while powering the system. In either case, it is not possible to obtain high quality EEGdata over long periods of time while the patient goes about their normal routine and daily activities. Long-termEEG recording is further complicated by the fact that electrodes applied to the scalp only maintain comfortable,low-impedance contact for limited periods of time. As a result, physicians commonly make clinical decisionsbased on limited and incomplete EEG information or, in clinical workflows for many neurological conditions,without any EEG information at all.The proposed project will advance the development of implantable and wearable EEG acquisition systems bydesigning miniaturized electronics for EEG data collection, storage, and transmission. Combined withspecialized electrodes made from highly biocompatible and durable organic electronic materials, the overallsolution will overcome the limitations of current instrumentation and allow for widespread use of long-termEEG, resulting in better diagnosis and management of neurological conditions and leading to improved patientoutcomes.

测量和记录来自大脑的电信号被称为脑电图（EEG），通常被用作许多神经系统疾病的诊断和治疗计划的一部分，包括癫痫、睡眠障碍、脑损伤等。使用目前的脑电图仪器，患者必须通过有线电极连接到记录硬件，或者在为系统供电时佩戴笨重的耳机来存储和/或传输脑电图数据。在任何一种情况下，当患者进行正常的日常活动时，都不可能长时间获得高质量的脑电图数据。由于电极只能在有限的时间内保持舒适的低阻抗接触，长期的meeg记录变得更加复杂。因此，医生通常根据有限和不完整的脑电图信息做出临床决策，或者在许多神经系统疾病的临床工作流程中，根本没有任何脑电图信息。该项目将通过设计用于脑电图数据收集、存储和传输的小型化电子设备，推进可植入和可穿戴脑电图采集系统的发展。结合由高度生物相容性和耐用的有机电子材料制成的专用电极，整体解决方案将克服当前仪器的局限性，并允许长期meeg的广泛使用，从而更好地诊断和管理神经系统疾病，并改善患者的预后。