Development and Characterization of an implantable system-on-a-chip for long-term ambulatory EEG monitoring

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The measurement and recording of electrical signals from the brain is known as electroencephalography (EEG)and is commonly used as part of the diagnosis and treatment planning for numerous neurological conditionsincluding epilepsy, sleep disorders, brain injury, and others. With current EEG instrumentation, the patientmust either be tethered to the recording hardware by wired electrodes, or wear a bulky headset to store and/ortransmit the EEG data while powering the system. In either case, it is not possible to obtain high quality EEGdata over long periods of time while the patient goes about their normal routine and daily activities. Long-termEEG recording is further complicated by the fact that electrodes applied to the scalp only maintain comfortable,low-impedance contact for limited periods of time. As a result, physicians commonly make clinical decisionsbased on limited and incomplete EEG information or, in clinical workflows for many neurological conditions,without any EEG information at all.The proposed project will advance the development of implantable and wearable EEG acquisition systems bydesigning miniaturized electronics for EEG data collection, storage, and transmission. Combined withspecialized electrodes made from highly biocompatible and durable organic electronic materials, the overallsolution will overcome the limitations of current instrumentation and allow for widespread use of long-termEEG, resulting in better diagnosis and management of neurological conditions and leading to improved patientoutcomes.