Next Generation Implantable Neural Interface Microsystems

下一代植入式神经接口微系统

• 批准号: RGPIN-2017-05658
• 负责人: Kassiri, Hossein
• 金额: $ 2.11万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=758061
• 关键词: Next; Generation; Implantable; Neural; Interface

Nature: In the past decade, implantable neural interface microsystems have shown promising results in detection and control of severe brain disorders. Accurate capture of these diseases, which often originate in multiple regions of the brain, demands microsystems with a rapidly-growing need for higher number of channels to acquire high-precision sensory data from a large area of the brain. This research program will respond to the rising technological challenges due to the scaling of implantable neural interfaces, by investigating a design paradigm shift from a centralized highly-integrated microsystem to a distributed wireless network of sensor nodes. Significance: The program will investigate the technical viability of such paradigm shift by (i) modeling, simulation, and prototype development and characterization to determine the optimal physical and electrical specifications of wireless free-floating single-chip sensor nodes that have antenna, electrodes, and electronic circuits integrated on them (ii) development and optimization of an inductive power transfer link that is resilient against movements and random environment variations surrounding sensor nodes, and (iii) investigating link throughput limitations and addressing data interference issues associated with employing a passive backscattering method that reuses the inductive power transfer link for sensory data communication.Outcomes: The proposed research program will advance science and technology in the areas of microelectronics and neuro-technology. The results from experimental characterization of the developed prototypes will be used to better understand and resolve the scalability limitations associated with the current state of technology for implantable sensory microsystems. Once fully realized, the proposed research will also lead to a fully-wireless ubiquitous sensing platform that will fill the technology gaps for conducting research not only in neuroscience, but also in several other fields including but not limited to biochemistry and bio-robotics.Benefits: There are over one billion people worldwide (3.6 million in Canada) who suffer from at least one type of neurological disorder. Successful completion of this program will enable the development of next generation implantable neural interfaces with application in both diagnostic and treatment of brain disorders in patients who are refractory to currently-available solutions. Moreover, implantable therapies for each one of epilepsy, Parkinson's and Alzheimer's diseases are estimated to have over a billion dollar market in North America. This research program will provide technology transfer opportunities in both forms of commercialization of the developed prototypes as a medical device, as well as licensing the developed circuit and system intellectual property to neuro-technology companies, including in Canada.

在过去的十年中，植入式神经接口微系统在检测和控制严重的大脑疾病方面显示出了有希望的结果。这些疾病通常起源于大脑的多个区域，准确捕获这些疾病需要快速增长的微系统，需要更多的通道来从大脑的大区域获取高精度的感觉数据。该研究计划将通过调查从集中式高度集成的微系统到传感器节点的分布式无线网络的设计范式转变，来应对由于可植入神经接口的扩展而带来的日益严峻的技术挑战。重要性：该计划将通过以下方式研究这种范式转变的技术可行性：（i）建模，仿真和原型开发和表征，以确定具有天线，电极，以及集成在其上的电子电路（ii）开发和优化感应功率传输链路，其对传感器节点周围的运动和随机环境变化具有弹性，以及（iii）调查链路吞吐量限制和解决与采用无源反向散射方法相关的数据干扰问题，该方法重复使用感应功率传输链路进行传感数据communication.Outcomes：拟议的研究计划将推进微电子和神经技术领域的科学技术。开发的原型的实验表征的结果将用于更好地理解和解决与植入式传感微系统的技术现状相关的可扩展性限制。一旦完全实现，拟议的研究还将产生一个全无线无处不在的传感平台，该平台将填补不仅在神经科学领域进行研究的技术空白，而且在其他几个领域进行研究，包括但不限于生物化学和生物机器人。好处：全球有超过10亿人（加拿大有360万人）患有至少一种类型的神经系统疾病。该项目的成功完成将使下一代植入式神经接口的开发成为可能，该接口可应用于诊断和治疗目前可用解决方案难以治疗的患者的脑部疾病。此外，用于癫痫、帕金森病和阿尔茨海默病中的每一种的植入式疗法估计在北美具有超过10亿美元的市场。该研究计划将以两种形式提供技术转让机会：将开发的原型作为医疗器械进行商业化，以及将开发的电路和系统知识产权许可给包括加拿大在内的神经技术公司。