The effects of Selko Elarom Poultry on intestinal inflammation in broiler chickens

球虫病是肉鸡的一种寄生虫病。球虫引起的病变是坏死性肠炎的前兆因素，这种疾病在世界范围内每年给家禽生产者造成60亿美元的经济损失。在常规生产中，球虫病和坏死性肠炎是通过抗球虫药和抗生素管理来预防和管理的。然而，在无抗生素饲养（RWA）计划中，禁止在鸟的一生中使用抗生素。在RWA生产中，球虫病可以通过接种疫苗来预防，但并非没有风险。疫苗含有活的寄生虫，这些寄生虫在肠道内复制多次，在此过程中损害器官。对肠道的损害导致炎症和肠道完整性标记物的减少，这些标记物与接种疫苗后体重增加的减少有关。促进肠道正常功能的饲料添加剂可能有助于减轻活疫苗引起的肠道损伤。由TrouwNutrition生产的Selko Elarom家禽（ElrM）是酚类化合物、短链和中链脂肪酸以及有机酸的协同混合物。Trouw Nutrition之前完成的内部研究表明，ElrM提高了饲料转化率，这是一项支持Elarom在RWA应用中使用的增长指数。然而，这些影响的机制基础尚未阐明。这是一个需要解决的重要问题，因为它将提供进一步的经验证据，以支持使用Selko Elarom家禽，并减少球虫病和疫苗接种的经济影响。因此，该公司想要研究的问题是，拟议工作的目的是研究Elarom对肉鸡肠道炎症和肠道完整性指标的影响。Trouw Nutrition没有专业知识来回答这个问题，随后与该领域的专家Wright博士合作。这项工作将为深入了解ElrM的作用机制提供重要的见解，并将是扩大ElrM在其他物种中的应用的重要一步。

Coccidiosis is a parasitic condition of broiler chickens. The lesions casued by coccidia are a pre-disposingfactor for necrotic enteritis, an ailment that is associated with world wide economic losses to poultry producersof > $6 billion annually. In conventional production, coccidiosis and necrotic enteritis are prevented andmanaged through anti-coccidial and antibiotic administration. However the use of antibiotics are prohibitedduring the bird's life in raised without antibiotic (RWA) feeding programs. In RWA production, coccidiosis canbe prevented through vaccination, yet not without risk. Vaccines contain live parasites, which replicate anumber of times through the intestines, damaging the organ in the process. Damage to the intestine results ininflammation and reductions in markers of gut integrity that have been linked to decreases in weight gainfollowing vaccination. Feed additives that promote proper intestinal functioning may prove beneficial inmitigating the intestinal damage induced by live vaccines. Selko Elarom Poultry (ElrM), produced by TrouwNutrition, is a synergistic blend of phenolic compounds, short and medium chain fatty acids, and organic acids.Previous in-house studies completed by Trouw Nutrition have demonstrated that ElrM improves feedconversion ratio, an index of growth supporting the use of Elarom in RWA applications. However, themechanistic underpinnings of these effects have not been elucidated. This is an important question to address,as it will provide further empirical evidence to support the use of Selko Elarom Poultry and reduce theeconomic impact of Coccidiosis and vaccination against it. Therefore the problem the company would like toinvestigate, and the objective of the proposed work is to examine the effects of Elarom on indices of intestinalinflammation and gut integrity in broiler chickens. Trouw Nutrition does not have the expertise to answer thisquestion and has subsequently partnered with Dr. Wright, an expert in this area. The work in this proposal willprovide important insight into the mechanisms of action of ElrM and will be an important step in expandingthe use of ElrM in other species.