The effects of Selko Elarom Poultry on intestinal inflammation in broiler chickens

Selko Elarom Poultry 对肉鸡肠道炎症的影响

• 批准号: 517522-2017
• 负责人: Wright, David
• 金额: $ 1.82万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=640232
• 关键词: effects; Selko; Elarom; Poultry; intestinal

Coccidiosis is a parasitic condition of broiler chickens. The lesions casued by coccidia are a pre-disposingfactor for necrotic enteritis, an ailment that is associated with world wide economic losses to poultry producersof > $6 billion annually. In conventional production, coccidiosis and necrotic enteritis are prevented andmanaged through anti-coccidial and antibiotic administration. However the use of antibiotics are prohibitedduring the bird's life in raised without antibiotic (RWA) feeding programs. In RWA production, coccidiosis canbe prevented through vaccination, yet not without risk. Vaccines contain live parasites, which replicate anumber of times through the intestines, damaging the organ in the process. Damage to the intestine results ininflammation and reductions in markers of gut integrity that have been linked to decreases in weight gainfollowing vaccination. Feed additives that promote proper intestinal functioning may prove beneficial inmitigating the intestinal damage induced by live vaccines. Selko Elarom Poultry (ElrM), produced by TrouwNutrition, is a synergistic blend of phenolic compounds, short and medium chain fatty acids, and organic acids.Previous in-house studies completed by Trouw Nutrition have demonstrated that ElrM improves feedconversion ratio, an index of growth supporting the use of Elarom in RWA applications. However, themechanistic underpinnings of these effects have not been elucidated. This is an important question to address,as it will provide further empirical evidence to support the use of Selko Elarom Poultry and reduce theeconomic impact of Coccidiosis and vaccination against it. Therefore the problem the company would like toinvestigate, and the objective of the proposed work is to examine the effects of Elarom on indices of intestinalinflammation and gut integrity in broiler chickens. Trouw Nutrition does not have the expertise to answer thisquestion and has subsequently partnered with Dr. Wright, an expert in this area. The work in this proposal willprovide important insight into the mechanisms of action of ElrM and will be an important step in expandingthe use of ElrM in other species.

球虫病是肉鸡的一种寄生虫病。球虫引起的病变是坏死性肠炎的诱发因素，这种疾病每年给全世界家禽生产者造成超过 60 亿美元的经济损失。在常规生产中，球虫病和坏死性肠炎是通过抗球虫和抗生素施用来预防和控制的。然而，在无抗生素饲养 (RWA) 饲养计划中，鸟的一生中禁止使用抗生素。在 RWA 生产中，可以通过疫苗接种来预防球虫病，但也存在风险。疫苗含有活寄生虫，它们会在肠道内复制多次，并在此过程中损害器官。肠道损伤会导致炎症和肠道完整性标记物的减少，而这些标记物与疫苗接种后体重增加的减少有关。促进肠道正常功能的饲料添加剂可能有助于减轻活疫苗引起的肠道损伤。 Selko Elarom Poultry (ElrM) 由 TrouwNutrition 生产，是酚类化合物、短链和中链脂肪酸以及有机酸的协同混合物。Trouw Nutrition 之前完成的内部研究表明，ElrM 可以提高饲料转化率，这是支持 Elarom 在 RWA 应用中使用的生长指数。然而，这些效应的机制基础尚未阐明。这是一个需要解决的重要问题，因为它将提供进一步的经验证据来支持 Selko Elarom Poultry 的使用并减少球虫病和疫苗接种对经济的影响。因此，该公司想要研究的问题和拟议工作的目标是检查 Elarom 对肉鸡肠道炎症和肠道完整性指数的影响。 Trouw Nutrition 没有专业知识来回答这个问题，因此与该领域的专家 Wright 博士合作。该提案中的工作将为 ElrM 的作用机制提供重要的见解，并将是扩大 ElrM 在其他物种中的使用的重要一步。