Improved powder production processes

该项目将继续开展工作，旨在了解工艺参数如何影响我们开发的用于冷冻干燥生物和医疗解决方案以生产粉末的现有技术。冷冻干燥的生物医药粉末不仅用于食品，也用于制药。我们将在这个项目中采用的技术被称为大气喷雾冷冻干燥（ASFD），它有可能比目前的方法更快、更经济，并且比目前的方法适用于更广泛的物质。在之前的Engage项目中，我们改进了AFSD设备的监控和过程控制。在提出的工作中，我们将研究不同工艺参数变化对用AFSD生产的粉末属性的影响。这项工作将旨在优化工艺参数，以生产具有给定期望性能的粉末。使用AFSD将探索使用感兴趣的制药配方的行业合作伙伴，并与传统的托盘冷冻干燥进行比较。作为拟议研究的一部分，我们将检查AFSD生产具有所需性能的干燥材料的能力，但与行业合作伙伴使用的其他方法相比，该方法可以减少处理时间和成本。此外，我们希望继续提高我们对工艺参数及其控制如何影响常压喷雾冷冻干燥材料基本特性的理解。

This project will continue work aimed at understanding how process parameters affect an existing technology developed by us for freeze-drying biological and medical solutions to produce powders. Freeze-dried bio-medical powders are used in pharmaceuticals as well as for food. The technology we will employ in this project is called atmospheric spray freeze drying (ASFD) and has the potential to be faster and more economical than current methods and to work for a wider variety of substances than allowed for by current methods. During our previous Engage grant, we improved the monitoring and process control of our AFSD equipment. In the proposed work, we will examine the effects of different process parameter variations on the attributes of the powders produced with AFSD. This work will aim towards optimization of process parameters to produce powders with given desired properties. Use of AFSD will be explored using pharmaceutical formulations of interest to the industry partner and comparison to conventional tray freeze-drying will be made. As part of the proposed research, we will examine the ability of AFSD to produce dried material with desired properties but with reduced processing time and cost compared to the other methods used by the industry partner. In addition, we wish to continue improving our understanding of how process parameters and their control affect the essential properties of atmospheric spray freeze dried material.