Super-resolution radial fluctuation microscope for 4D imaging of cells and cellular dynamics

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Our 6 research groups use a state-of-the-art custom-built spinning-disk confocal microscopy originally funded by investments from both CFI and NSERC. This microscope is cable of both fixed and high-speed live-cell imaging that is central to our research programs, and is used to observe a wide-array of proteins (e.g. mitochondrial, DNA repair and RNA-binding factors), cellular processes (e.g. DNA repair, synapse formation, autophagy, host-pathogen interactions) and structures (e.g. nuclear subdomains, synapses, mitochondria, autophagosomes and stress granules) within several different organisms including protists, bacteria, viruses, and both human and zebrafish cells.