On-Column Fluorescence Detection for High-Throughput Identification of Cysteine Reactive Chemicals in the Environment

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Increasing incidence of diseases, such as cancer and diabetes, in Canada and worldwide in recent decades has been associated with environmental pollution. However, preventative assessment of the health risks of environmental chemicals leaves much to be desired since the toxicities for most environmental chemicals remain unidentified. Systematic investigation of the toxicities of immense number of environmental chemicals (over 70,000 in commercial use) is implausible given the time and financial cost of current animal-based toxicity tests. Oxidative stress is a common toxicity of special concern since it is proposed as the primary toxicity of air particulate matter (PM) and disinfection by-products (DBPs) in drinking water. Development of high-throughput methods to identify the toxic chemicals that cause oxidative stress in PM and drinking water is in urgent need.