Operations and Maintenance Support: UBC Regional Structural Biology Facility

运营和维护支持：UBC 区域结构生物学设施

• 批准号: RTI-2017-00193
• 负责人: McIntosh, Lawrence
• 金额: $ 10.93万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642374
• 关键词: Operations; Maintenance; Support; UBC; Regional

Structural biology is a branch of the Life Sciences that seeks to provide atomic-level descriptions of the three-dimensional structures of biological molecules, including proteins, DNA, RNA and sugars. This structural information is critical for understanding the diverse functions of these biomolecules in living cells, and provides a "molecular blueprint" for applications spanning protein engineering to drug development. Modern structural biology is dependent upon three cornerstone technologies: nuclear magnetic resonance (NMR) spectroscopy for investigating the structures and motions of small to medium sized biomolecues, X-ray crystallography for determining the highest resolution structures of a wide range of proteins, nucleic acids and carbohydrates, and cryo-electron microscopy for near atomic level characterization of very large macromolecular complexes. Each of these complementary technologies relies on access to sophisticated instrumentation and expert personnel in order to solve the most challenging problems of the Life Sciences.

结构生物学是生命科学的一个分支，旨在提供生物分子（包括蛋白质、DNA、RNA和糖）的三维结构的原子级描述。这些结构信息对于理解这些生物分子在活细胞中的不同功能至关重要，并为从蛋白质工程到药物开发的应用提供了“分子蓝图”。现代结构生物学依赖于三项基石技术：用于研究中小型生物分子的结构和运动的核磁共振（NMR）光谱学，用于确定多种蛋白质、核酸和碳水化合物的最高分辨率结构的X射线晶体学，以及用于超大大分子复合物近原子水平表征的低温电子显微镜。这些互补技术中的每一种都依赖于先进的仪器和专家人员，以解决生命科学中最具挑战性的问题。