Canadian Research Chair in Vascular Optical Imaging

加拿大血管光学成像研究主席

• 批准号: CRC-2014-00034
• 负责人: Lesage, Frédéric
• 金额: $ 14.57万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642471
• 关键词: Canadian; Research; Chair; Vascular; Optical

Correlations have been established between vascular disorders and cognitive impairments, and also between cardiovascular risk factors and brain white matter lesions. Understanding beyond those correlations how the brain deteriorates in these diseases or if cardiovascular factors contribute to this deterioration is a central question of my research and is essential to help clinicians develop new therapies so that both heart and mind are preserved with aging. The main goal of this research program is to investigate, in the whole brain and at very high resolution, the role of changes in brain microvasculature properties associated with cardiovascular diseases on brain function and structure. This will be achieved by developing state-of-the-art optical imaging techniques combined with biophysical models that aim to explain and predict how these changes will impact clinical imaging measures both in terms of anatomy and function. Our predictions will then be translated to clinical applications using the same models.

血管疾病和认知障碍之间以及心血管危险因素和脑白色病变之间的相关性已经建立。除了这些相关性之外，了解大脑在这些疾病中如何恶化，或者心血管因素是否有助于这种恶化，这是我研究的一个中心问题，对于帮助临床医生开发新的治疗方法至关重要，以便心脏和心灵都能随着年龄的增长而得到保护。该研究计划的主要目标是在整个大脑中以非常高的分辨率研究与心血管疾病相关的脑微血管特性变化对脑功能和结构的作用。这将通过开发最先进的光学成像技术与生物物理模型相结合来实现，这些模型旨在解释和预测这些变化将如何影响解剖和功能方面的临床成像措施。然后，我们的预测将使用相同的模型转化为临床应用。