Environmental Radiobiology

环境放射生物学

• 批准号: CRC-2017-00228
• 负责人: Mothersill, Carmel
• 金额: $ 3.64万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642840
• 关键词: Environmental; Radiobiology

This proposal seeks to investigate the phenomenology and mechanisms involved in the physical transmission of radiation induced bystander signals and downstream events subsequent to the initial interaction of radiation with matter. We have demonstrated that the initial events occur without the need for transfer or sharing of liquid medium between cells precluding a wholly chemical mechanism. The elucidation of biophysical, biochemical and bioenergetics pathways involved in signal transduction is the main objective of the proposal, however the results should identify new targets for radiation protection and for cancer therapy and should result in new concepts in radiobiology.

这一提议试图调查辐射与物质最初相互作用之后辐射引起的旁观者信号和下游事件的物理传输所涉及的现象学和机制。我们已经证明，最初的事件发生时，细胞之间不需要转移或共享液体介质，这排除了完全的化学机制。阐明参与信号转导的生物物理、生化和生物能量途径是该提案的主要目标，然而，结果应确定辐射防护和癌症治疗的新靶点，并应产生放射生物学的新概念。