Proteomics and Bioanalytical mass spectrometry

蛋白质组学和生物分析质谱

• 批准号: 1000224624-2010
• 负责人: Thibault, Pierre
• 金额: $ 14.57万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642915
• 关键词: Proteomics; Bioanalytical; mass; spectrometry

The Chair enabled leading-edge discoveries in Proteomics and Bioanalytical Mass Spectrometry and fostered a creative multi-disciplinary training environment of international caliber for trainees and collaborators. We established a vibrant and innovative research program in Mass Spectrometry and quantitative proteomics to decipher the molecular mechanisms regulating the function of proteins involved in immunity and cancer. We developed novel approaches to profile protein modifications and immunogenic molecules that provided key insights on cell signaling and antigen presentation in normal and neoplastic cells. Our work led to publications in high impact journals, patents and technology transfer to the industry.

主席促进了蛋白质组学和生物分析质谱的前沿发现，并为学员和合作者创造了一个具有国际水准的创造性多学科培训环境。我们在质谱和定量蛋白质组学方面建立了一个充满活力和创新的研究项目，以破译调节免疫和癌症相关蛋白质功能的分子机制。我们开发了新的方法来描述蛋白质修饰和免疫原性分子，为正常细胞和肿瘤细胞的细胞信号传导和抗原呈递提供了关键的见解。我们的工作导致在高影响力期刊上发表，专利和技术转移到行业。