Molecular Interactions and Structural Biology

分子相互作用和结构生物学

• 批准号: CRC-2016-00183
• 负责人: Boulanger, Martin
• 金额: $ 7.29万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=645969
• 关键词: Molecular; Interactions; Structural; Biology

Parasitic diseases pose a major threat to human and animal health resulting in significant morbidity and mortality, and negative economic impact on a global scale. The goal of the proposed research program is to elucidate the underlying mechanisms of how parasitic pathogens establish infection and cause disease. To achieve this goal, protein complexes that are central to parasite virulence and transmission will be structurally and functionally dissected using cutting edge biophysical techniques. The expected long term, outcome will be to design and develop novel diagnostics and therapeutics to control these devastating pathogens.

寄生虫病对人类和动物健康构成重大威胁，导致严重的发病率和死亡率，并在全球范围内产生负面经济影响。拟议的研究计划的目标是阐明寄生病原体如何建立感染和引起疾病的潜在机制。为了实现这一目标，蛋白质复合物是中央寄生虫毒力和传输将结构和功能解剖使用尖端的生物物理技术。预期的长期结果将是设计和开发新的诊断和治疗方法来控制这些毁灭性的病原体。