An examination of fatigue development during intense motor output(s)
检查剧烈运动输出期间的疲劳发展
基本信息
- 批准号:RGPIN-2018-03876
- 负责人:
- 金额:$ 2.11万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The human central nervous system (i.e. brain and spinal cord) and how it functions to produce, and adapt to, different patterns of muscle contractions and movement is very complex. Generally speaking, for humans to move, the brain activates motor circuitry within the brainstem and spinal cord, which activates nerve cells (i.e. spinal motoneurones) that project to and activate skeletal muscle. When we start to execute a movement there is an increase in the excitability in the brain and spinal cord. The manner in which the brain and spinal cord are activated depends on the type of human movement and fatigue status. With increased neuromuscular fatigue our ability to physically exert is substantially reduced. This has been shown following isometric and isotonic contractions. In part, the reduced physical exertion is due to decreased muscle activation, altered corticospinal (supraspinal and spinal) excitability and increased feedback from our pain receptors. However, very little is known about how neuromuscular fatigue is developed during high-intensity rhythmic movements. Over the next 5 years, studies from my lab will take a mechanistic approach to discover how motor output is altered due to the development of neuromuscular fatigue during maximal arm-cycling sprints. In phase 1, we will determine the role of the elbow flexors in the development of this fatigue and determine if arm-cranking type alters this fatigue. In phase 2, we will determine how exercise training affects the development of neuromuscular fatigue during arm-cycling sprints. In each phase we will be using a series of novel stimulation paradigms to discover changes in the peripheral nervous system (i.e. skeletal muscle properties) and central nervous system (i.e. corticospinal excitability) properties. Our outcomes have the potential to contribute not only to our understanding of basic neurophysiology underlying human neuromuscular fatigue of the elbow flexors and extensors during arm-cycling sprints, but may also prove useful in understanding neuromuscular fatigue mechanisms. The outcomes may have broad potential impacts such as on sports training, sports medicine, occupational safety, and physical impairments, etc.
人类中枢神经系统(即大脑和脊髓)以及它如何产生和适应不同的肌肉收缩和运动模式是非常复杂的。一般来说,为了使人类运动,大脑激活脑干和脊髓内的运动电路,从而激活投射到骨骼肌并激活骨骼肌的神经细胞(即脊髓运动神经元)。当我们开始执行一个动作时,大脑和脊髓的兴奋性会增加。大脑和脊髓被激活的方式取决于人体运动的类型和疲劳状态。随着神经肌肉疲劳的增加,我们身体运动的能力大大降低。这在等距收缩和等张收缩中得到了证明。在某种程度上,体力消耗的减少是由于肌肉激活的减少,皮质脊髓(棘上和脊柱)兴奋性的改变以及疼痛感受器反馈的增加。然而,人们对高强度有节奏的运动中神经肌肉疲劳是如何产生的知之甚少。在接下来的5年里,我的实验室的研究将采用机械方法来发现在最大限度的手臂循环冲刺期间,由于神经肌肉疲劳的发展,运动输出是如何改变的。在第一阶段,我们将确定肘关节屈肌在这种疲劳发展中的作用,并确定手臂曲柄类型是否改变这种疲劳。在第二阶段,我们将确定运动训练如何影响手臂循环冲刺期间神经肌肉疲劳的发展。在每个阶段,我们将使用一系列新的刺激范式来发现周围神经系统(即骨骼肌特性)和中枢神经系统(即皮质脊髓兴奋性)特性的变化。我们的研究结果不仅有助于我们理解人类肘关节屈伸肌神经肌肉疲劳的基本神经生理学,而且可能有助于理解神经肌肉疲劳的机制。研究结果可能对运动训练、运动医学、职业安全、身体损伤等方面产生广泛的潜在影响。
项目成果
期刊论文数量(0)
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{{ truncateString('Button, Duane', 18)}}的其他基金
An examination of fatigue development during intense motor output(s)
检查剧烈运动输出期间的疲劳发展
- 批准号:
RGPIN-2018-03876 - 财政年份:2022
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
An examination of fatigue development during intense motor output(s)
检查剧烈运动输出期间的疲劳发展
- 批准号:
RGPIN-2018-03876 - 财政年份:2021
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
An examination of fatigue development during intense motor output(s)
检查剧烈运动输出期间的疲劳发展
- 批准号:
RGPIN-2018-03876 - 财政年份:2020
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
An examination of fatigue development during intense motor output(s)
检查剧烈运动输出期间的疲劳发展
- 批准号:
RGPIN-2018-03876 - 财政年份:2019
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
Electrophysiological and morphological properties of normal and regenerated hippocampus neurones before and after stroke and rehabiliation
中风和康复前后正常和再生海马神经元的电生理和形态学特性
- 批准号:
357653-2008 - 财政年份:2008
- 资助金额:
$ 2.11万 - 项目类别:
Postdoctoral Fellowships
Spinal Cord Responses to Active and Passive Exercise
脊髓对主动和被动运动的反应
- 批准号:
302999-2004 - 财政年份:2005
- 资助金额:
$ 2.11万 - 项目类别:
Postgraduate Scholarships - Doctoral
Spinal Cord Responses to Active and Passive Exercise
脊髓对主动和被动运动的反应
- 批准号:
302999-2004 - 财政年份:2004
- 资助金额:
$ 2.11万 - 项目类别:
Postgraduate Scholarships - Doctoral
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An examination of fatigue development during intense motor output(s)
检查剧烈运动输出期间的疲劳发展
- 批准号:
RGPIN-2018-03876 - 财政年份:2022
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual