Regulation of membrane trafficking by the PACS family of proteins

PACS 蛋白家族对膜运输的调节

• 批准号: 435677-2013
• 负责人: Dikeakos, DimitriosJimmy
• 金额: $ 2.55万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=649292
• 关键词: Regulation; membrane; trafficking; PACS; family

The correct movement of proteins in the various cellular compartments is vital to the proper function of a cell. We study a family of proteins called the Phosphofurin Acidic Cluster Sorting Proteins (PACS-1 and 2) that specifically interact with numerous client proteins and traffic them to precise cellular locations to regulate specific cellular functions such as the regulation of cell death. It remains unknown how PACS can interact with numerous cellular partners and exert different affects. Our work will aim to decipher specific domains on the PACS proteins and on their client proteins that enable these interactions. Furthermore, we will study specific signals located in the PACS proteins enabling their localization to different cellular compartments. Together, these studies will advance our knowledge of basic fundamental principles ensuring the proper localization of protein to various cellular compartments.**

蛋白质在各种细胞区室中的正确运动对细胞的正常功能至关重要。我们研究了一个名为磷酸弗林酸性簇分选蛋白（PACS-1和2）的蛋白质家族，这些蛋白质与许多客户蛋白质特异性相互作用，并将它们运送到精确的细胞位置，以调节特定的细胞功能，如细胞死亡的调节。PACS如何与众多的细胞伙伴相互作用并发挥不同的作用仍然是未知的。我们的工作将旨在破译PACS蛋白及其客户蛋白上的特定结构域，使这些相互作用成为可能。此外，我们将研究位于PACS蛋白中的特定信号，使其定位于不同的细胞区室。总之，这些研究将推进我们对确保蛋白质正确定位于各种细胞区室的基本原理的知识。