Characterizing the mechanical properties and biological impact of implantable cartilage replacement gels

表征可植入软骨替代凝胶的机械性能和生物学影响

• 批准号: 531466-2018
• 负责人: Ehrlicher, Allen
• 金额: $ 1.82万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=649959
• 关键词: Characterizing; mechanical; properties; biological; impact

Oligo Medic of Laval Quebec endeavors to provide biomaterial implants as cartilage replacements as**minimally invasive solutions to human clinical challenges. During aging and injury, these tissues can be**degraded, causing a loss in mobility and/or significant pain. These implants may replace more invasive**approaches such as joint replacements, and will potentially treat these changes to improve quality of life for**patients.**Theses mechanics of soft-tissues can be quite complex, and it has become well-established that**microenvironment mechanics can influence cell activity as much as temperature or pH. The biocompatibility**of these materials with cells hinges on quantifying these mechanics, characterizing cell biology in these implant**materials, and tuning the mechanics to achieve desired biological outcomes. Resolving the mechanics of these**materials and impact on cell activity is essential in developing effective impant treatment for orthopedic**patients, from sports medicine to geriatric therapy.**In this proposal, Professor Allen Ehrlicher and Dr Khavari from McGill are working together with Oligo Medic**to characterize the mechanics of these implant gels, the cell activity in them, and innovate new approaches to**modify their mechanics. Drs Ehrlicher & Khavari are experts in the material properties of cells and tissues,**while Oligo Medic has an established track record in novel implant material synthesis. This team expects that**their collaboration will provide insight into the biocompatibility of these implants, and how to optimize them**for human use. This will provide measurements as to how failing joints may be repaired, aiding medical**doctors in treating patients with joint disorders or trauma.

魁北克拉瓦尔的Oligo Medic致力于提供生物材料植入物作为软骨替代物，作为人类临床挑战的微创解决方案。在老化和损伤过程中，这些组织可能会退化，导致活动能力丧失和/或严重疼痛。这些植入物可能会取代更具侵入性的方法，如关节置换术，并可能治疗这些变化，以改善 ** 患者的生活质量。软组织的这些力学可能相当复杂，并且已经确定微环境力学可以像温度或pH值一样影响细胞活性。这些材料与细胞的生物相容性取决于量化这些力学，表征这些植入材料中的细胞生物学，并调整力学以实现所需的生物学结果。解决这些材料的力学和对细胞活性的影响对于为骨科 ** 患者开发有效的植入治疗至关重要，从运动医学到老年治疗。在这项提案中，来自麦吉尔大学的艾伦埃利彻教授和卡瓦里博士正在与奥利戈医疗公司 ** 合作，研究这些植入凝胶的力学特性、其中的细胞活性，并创新新的方法来 ** 改变它们的力学特性。Ehrlicher和Khavari博士是细胞和组织材料特性方面的专家，** 而Oligo Medic在新型植入材料合成方面有着良好的记录。该团队希望 ** 他们的合作将深入了解这些植入物的生物相容性，以及如何优化它们 ** 供人类使用。这将提供如何修复失败关节的测量，帮助医生治疗关节疾病或创伤患者。