Microscale propulsion and pumping in complex fluids

复杂流体中的微尺度推进和泵送

• 批准号: RGPIN-2014-06577
• 负责人: Elfring, Gwynn
• 金额: $ 1.82万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=650048
• 关键词: Microscale; propulsion; pumping; complex; fluids

The development of biomimetic synthetic swimming microorganisms (micro-swimmers), opens the door to a wide spectrum of potential applications where very small scales are required. These micro-swimmers could be used to perform internal surgery or drug delivery in the human body, used as autonomous roving chemical sensors or even for microscale assembly. An anchored micro-swimmer can act as a microscale pump, mimicking cilia found in nature, a very effective method for transport and mixing at the cellular scale. A difficulty in the design of these synthetic micro-swimmers and micro-pumps is that the physics of fluids at such small scales is fundamentally different than that of everyday observable phenomena and often quite unintuitive. At these scales viscous forces are dominant and inertia is negligible hence familiar methods of locomotion and pumping can be completely ineffective. A particular challenge in the design of these micro-devices for use in industrial or biological applications is that the relevant fluids are often non-Newtonian. Despite the innovative experimental strides being made in fabricating these biomimetic devices, scientific progress must be made to properly characterize their mechanics in complex systems and fluids. Developing this understanding is critical if these devices are to progress from simply a proof-of-concept to industrial and commercial viability, and it is vital for applications in healthcare. It is proposed here to develop a research program on the mechanics of synthetic micro-swimmers and micro-pumps in complex fluids and systems, including scenarios where the fluid may contain microstructure, and where the interaction of many swimmers (collective motion) may be crucial.

仿生合成游泳微生物(微型游泳者)的发展，为需要非常小规模的广泛的潜在应用打开了大门。这些微型游泳者可以用来在人体内进行内部手术或药物输送，用作自主漫游的化学传感器，甚至用于微型组装。锚定的微型游泳者可以充当微型泵，模仿自然界中发现的纤毛，这是在细胞尺度上运输和混合的一种非常有效的方法。这些合成微型游泳器和微型泵的设计中的一个困难是，在如此小的尺度上，流体的物理性质与日常可观察到的现象有根本的不同，而且往往相当不直观。在这些尺度上，粘性力占主导地位，惯性可以忽略不计，因此常见的运动和抽水方法可能完全无效。在设计这些用于工业或生物应用的微型设备时，一个特别的挑战是相关的流体通常是非牛顿流体。尽管在制造这些仿生装置方面取得了创新的实验进展，但必须取得科学进展，以适当地描述它们在复杂系统和流体中的机制。如果这些设备要从简单的概念验证发展到工业和商业可行性，发展这种理解是至关重要的，这对于医疗保健应用也是至关重要的。这里建议开发一个关于合成微泳者和微泵在复杂流体和系统中的力学的研究计划，包括流体可能含有微观结构的场景，以及许多游泳者的相互作用(集体运动)可能是关键的场景。