Hemodynamics of device treated sidewall cerebral aneurysms**

装置治疗侧壁脑动脉瘤的血流动力学**

• 批准号: 534003-2018
• 负责人: Grecov, Dana
• 金额: $ 1.82万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=652388
• 关键词: Hemodynamics; device; treated; sidewall; cerebral

Cerebral aneurysms are cerebrovascular abnormality characterized by the weakening and dilation of a localized area of the wall of a cerebral artery. The reasons for aneurysm initiation, growth, and rupture are complicated and not well understood. Generally, it is recognized that hemodynamics play a key role in these processes given that the flow behavior is dependent on the geometrical characteristics of the flow domain. Stents are often deployed to treat cerebral aneurysms on where flow alterations occur within the aneurysm sac following the stent deployment.**Evasc is a medical device company focusing on developing leading edge solutions for treating cerebral aneurysms. Within Evasc's product portfolio, there is a need to further refine existing stent for treating sidewall aneurysms. Given that the current modular experimental setup has been developed at the Industrial and Biological Multiphysics Laboratory at UBC and can easily be adapted to be used for the investigation of sidewall cerebral aneurysms, a thorough investigation will be conducted to determine the effects of their anatomical characteristics on the effectiveness of different stents. **The main objective of this project is to investigate the effectiveness of existing endovascular stents, provided by Evasc, under the various anatomical configurations of sidewall cerebral aneurysms using our in-house developed modular cardiovascular flow simulator as well as Computational Fluid Dynamics (CFD) studies. Based on the results from this project, Evasc will iterate the design of their stent (eCLIPs) to achieve similar or improved flow effects compared to other devices. **

脑动脉瘤是脑血管异常，其特征是脑动脉壁的局部区域弱化和扩张。 动脉瘤启动，生长和破裂的原因很复杂且不良好。 通常，鉴于流动行为取决于流动结构域的几何特征，因此血液动力学在这些过程中起着关键作用。支架部署后，通常部署支架来治疗脑动脉瘤在动脉瘤囊内发生流动变化的位置。在EVASC的产品组合中，有必要进一步完善现有的支架来治疗侧壁动脉瘤。鉴于当前的模块化实验设置是在UBC的工业和生物多物理实验室开发的，并且可以轻松地适应用于研究侧壁大脑动脉瘤，因此将进行彻底的研究，以确定其解剖学特征对不同支架有效性的影响。 **该项目的主要目的是使用我们内部开发的模块化心血管流动模拟器以及计算流体动力学（CFD）研究，研究EVASC提供的现有血管内支架的有效性。根据该项目的结果，EVASC将迭代其支架（ECLIP）的设计，以与其他设备相比，获得相似或改善的流动效应。 **