Finding important associations in genetic and genomic data

寻找遗传和基因组数据中的重要关联

基本信息

  • 批准号:
    RGPIN-2014-04989
  • 负责人:
  • 金额:
    $ 0.8万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2018
  • 资助国家:
    加拿大
  • 起止时间:
    2018-01-01 至 2019-12-31
  • 项目状态:
    已结题

项目摘要

The upcoming era of research in genetics and genomics can be characterized as a data integration era. By combining various kinds of data, measured possibly in different ways, at different times or tissues, or from several sources, the hope is to better understand what are the relevant factors influencing disease or traits, and how they are linked together. This ongoing program of research has the long-term objective of developing statistical methods applicable to analysis of high-throughput genetic and genomic data of various types, with the over-arching theme of better using information from multiple sources. Recent progress from my previous NSERC Discovery Grant (such as developing and implementing a stratified false discovery rate approach for interpreting the results of genome-wide association studies, or investigating pathway methods for rare genetic variants), has led to the main objectives proposed here over the next five years. **The two main objectives are: **(1) When performing a large number of tests of significance, methods are proposed that will improve the ranking of the results by incorporating external information. From a ranked list of results, the most interesting ones are selected for further investigation in subsequent studies. Therefore obtaining improved rankings implies not only a better power to find true signals, but also a more effective use of resources for the follow-up research. I propose methodological improvements through effective understanding of the correlations between the tests, and using external genomic annotation information.**(2) Since the number of quantities that can be measured in genomics is so much larger than the number of individuals, it is easy to develop a predictive model that is optimized for one single data set, but performs poorly on new data. In this second objective, the goal is to address this concern in two ways. Firstly, I propose to work on development of data-type-specific methods for defining summaries that capture the intrinsic signals in the data in a much smaller number of measures. Then secondly, I plan to develop ways of combining these summary signals across different types of data, to give better accuracy of the prediction models.**Whenever possible, the proposed methods will be programmed and released as publicly available software packages. Hence, the body of work developed through this proposal will be beneficial to collaborators who are generating massive genetic and genomic data sets, and who are searching for effective methods of analysis.
即将到来的遗传学和基因组学研究时代可以被描述为数据集成时代。通过组合可能以不同方式、在不同时间或组织或从几个来源测量的各种数据,希望能更好地了解哪些相关因素影响疾病或特征,以及它们是如何联系在一起的。这项正在进行的研究计划的长期目标是开发适用于分析各种类型的高通量遗传和基因组数据的统计方法,其总体主题是更好地利用来自多个来源的信息。我之前的NSERC Discovery Grant取得的最新进展(如开发和实施分层错误发现率方法来解释全基因组关联研究的结果,或研究罕见基因变异的途径方法),导致了未来五年这里提出的主要目标。**两个主要目标是:**(1)在进行大量有意义的测试时,提出了通过纳入外部信息来提高结果排名的方法。从排序的结果列表中,选出最有趣的结果,以便在后续研究中进行进一步研究。因此,获得更好的排名不仅意味着更好地发现真实信号的能力,也意味着更有效地利用资源进行后续研究。我建议通过有效了解测试之间的相关性和使用外部基因组注释信息来改进方法。**(2)由于基因组学中可以测量的数量比个体数量大得多,很容易开发一个针对单个数据集进行优化的预测模型,但在新数据上的表现很差。在第二个目标中,目标是通过两种方式解决这一关切。首先,我建议开发特定于数据类型的方法,用于定义摘要,以更少的度量捕获数据中的内在信号。其次,我计划开发将这些不同类型数据的汇总信号组合在一起的方法,以提高预测模型的准确性。**只要有可能,建议的方法将作为公开可用的软件包进行编程和发布。因此,通过这项提议开展的工作将有利于正在生成大量遗传和基因组数据集的合作者,以及正在寻找有效分析方法的合作者。

项目成果

期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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Greenwood, Celia其他文献

The G84E mutation of HOXB13 is associated with increased risk for prostate cancer: results from the REDUCE trial
  • DOI:
    10.1093/carcin/bgt055
  • 发表时间:
    2013-06-01
  • 期刊:
  • 影响因子:
    4.7
  • 作者:
    Chen, Zhuo;Greenwood, Celia;Xu, Jianfeng
  • 通讯作者:
    Xu, Jianfeng
Whole-genome sequence-based analysis of thyroid function.
  • DOI:
    10.1038/ncomms6681
  • 发表时间:
    2015-03-06
  • 期刊:
  • 影响因子:
    16.6
  • 作者:
    Taylor, Peter N.;Porcu, Eleonora;Chew, Shelby;Campbell, Purdey J.;Traglia, Michela;Brown, Suzanne J.;Mullin, Benjamin H.;Shihab, Hashem A.;Min, Josine;Walter, Klaudia;Memari, Yasin;Huang, Jie;Barnes, Michael R.;Beilby, John P.;Charoen, Pimphen;Danecek, Petr;Dudbridge, Frank;Forgetta, Vincenzo;Greenwood, Celia;Grundberg, Elin;Johnson, Andrew D.;Hui, Jennie;Lim, Ee M.;McCarthy, Shane;Muddyman, Dawn;Panicker, Vijay;Perry, John R. B.;Bell, Jordana T.;Yuan, Wei;Relton, Caroline;Gaunt, Tom;Schlessinger, David;Abecasis, Goncalo;Cucca, Francesco;Surdulescu, Gabriela L.;Woltersdorf, Wolfram;Zeggini, Eleftheria;Zheng, Hou-Feng;Toniolo, Daniela;Dayan, Colin M.;Naitza, Silvia;Walsh, John P.;Spector, Tim;Smith, George Davey;Durbin, Richard;Richards, J. Brent;Sanna, Serena;Soranzo, Nicole;Timpson, Nicholas J.;Wilson, Scott G.
  • 通讯作者:
    Wilson, Scott G.

Greenwood, Celia的其他文献

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{{ truncateString('Greenwood, Celia', 18)}}的其他基金

New directions in genetic association studies
遗传关联研究的新方向
  • 批准号:
    RGPIN-2019-04482
  • 财政年份:
    2022
  • 资助金额:
    $ 0.8万
  • 项目类别:
    Discovery Grants Program - Individual
New directions in genetic association studies
遗传关联研究的新方向
  • 批准号:
    RGPIN-2019-04482
  • 财政年份:
    2021
  • 资助金额:
    $ 0.8万
  • 项目类别:
    Discovery Grants Program - Individual
New directions in genetic association studies
遗传关联研究的新方向
  • 批准号:
    RGPIN-2019-04482
  • 财政年份:
    2020
  • 资助金额:
    $ 0.8万
  • 项目类别:
    Discovery Grants Program - Individual
New directions in genetic association studies
遗传关联研究的新方向
  • 批准号:
    RGPIN-2019-04482
  • 财政年份:
    2019
  • 资助金额:
    $ 0.8万
  • 项目类别:
    Discovery Grants Program - Individual
Finding important associations in genetic and genomic data
寻找遗传和基因组数据中的重要关联
  • 批准号:
    RGPIN-2014-04989
  • 财政年份:
    2017
  • 资助金额:
    $ 0.8万
  • 项目类别:
    Discovery Grants Program - Individual
Finding important associations in genetic and genomic data
寻找遗传和基因组数据中的重要关联
  • 批准号:
    RGPIN-2014-04989
  • 财政年份:
    2016
  • 资助金额:
    $ 0.8万
  • 项目类别:
    Discovery Grants Program - Individual
Finding important associations in genetic and genomic data
寻找遗传和基因组数据中的重要关联
  • 批准号:
    RGPIN-2014-04989
  • 财政年份:
    2015
  • 资助金额:
    $ 0.8万
  • 项目类别:
    Discovery Grants Program - Individual
Finding important associations in genetic and genomic data
寻找遗传和基因组数据中的重要关联
  • 批准号:
    RGPIN-2014-04989
  • 财政年份:
    2014
  • 资助金额:
    $ 0.8万
  • 项目类别:
    Discovery Grants Program - Individual
Identifying useful predictors from genome-wide SNP association studies
从全基因组 SNP 关联研究中识别有用的预测因子
  • 批准号:
    239108-2008
  • 财政年份:
    2013
  • 资助金额:
    $ 0.8万
  • 项目类别:
    Discovery Grants Program - Individual
Identifying useful predictors from genome-wide SNP association studies
从全基因组 SNP 关联研究中识别有用的预测因子
  • 批准号:
    239108-2008
  • 财政年份:
    2012
  • 资助金额:
    $ 0.8万
  • 项目类别:
    Discovery Grants Program - Individual

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