Microfluidic bioreactors for perfusion of 3D bioprinted tissues

3D打印改变了包括生物医学和组织工程在内的许多应用的实践方式。特别是，3D打印现在被用于血管组织的生物打印和药物输送。现有的3D生物打印机存在一种被称为灌流系统的模拟输送系统，它为细胞生物打印的水凝胶提供营养。这项研究与3D生物打印领域的先驱公司之一合作，旨在开发一种基于微流控的灌流系统，用于向3D组织输送营养、氧气和药物。这些灌流系统将有利于3D打印行业大幅扩大对血管组织进行长期细胞培养、疾病建模和药物测试的能力。该项目的行业合作伙伴Aspect BiosSystems是一家为生物打印提供解决方案的领先科技公司。这些灌流系统将有利于Aspects BiosSystems大幅扩展其在血管组织上进行长期细胞培养、疾病建模和药物测试的能力。灌流系统的进步将打开新的市场，并将提高公司的竞争力。

3D printing has changed the ways of practice in many applications including biomedical and tissue engineering. In particular, 3D printing is now used for the bioprinting of vascular tissues and drug delivery. The existing 3D bioprinters suffer from a mimetic delivery system, known as perfusion system, to provide nutrients to cell-laden bioprinted hydrogels. In partnership with one of the pioneering companies in 3D bioprinting, this research aims at developing a microfluidic based perfusion system for the delivery of nutrients, oxygen and drugs to 3D tissues. These perfusion systems will benefit 3D printing industry in drastically expanding the capability for long-term cell culture, disease modeling and drug testing on vascular tissues. The industry partner for this project, Aspect Biosystems, is a leading tech company providing solutions for bioprinting. These perfusion systems will benefit Aspect Biosystems in drastically expanding their capability for long-term cell culture, disease modeling and drug testing on vascular tissues. The advancement in the perfusion system will open up new markets and will improve company competitiveness.****