Microfluidic bioreactors for perfusion of 3D bioprinted tissues

3D打印改变了许多应用的实践方式，包括生物医学和组织工程。特别是，3D打印现在用于血管组织和药物输送的生物打印。现有的3D生物打印机受到称为灌注系统的模拟递送系统的影响，以向载有细胞的生物打印水凝胶提供营养。该研究与3D生物打印领域的先驱公司之一合作，旨在开发一种基于微流体的灌注系统，用于向3D组织输送营养物质，氧气和药物。这些灌注系统将使3D打印行业受益，大大扩展血管组织长期细胞培养、疾病建模和药物测试的能力。该项目的行业合作伙伴Aspect Biosystems是一家领先的技术公司，为生物打印提供解决方案。这些灌注系统将使Aspect Biosystems大大扩展其在血管组织上进行长期细胞培养、疾病建模和药物测试的能力。灌注系统的进步将开辟新的市场，并将提高公司的竞争力。

3D printing has changed the ways of practice in many applications including biomedical and tissue engineering. In particular, 3D printing is now used for the bioprinting of vascular tissues and drug delivery. The existing 3D bioprinters suffer from a mimetic delivery system, known as perfusion system, to provide nutrients to cell-laden bioprinted hydrogels. In partnership with one of the pioneering companies in 3D bioprinting, this research aims at developing a microfluidic based perfusion system for the delivery of nutrients, oxygen and drugs to 3D tissues. These perfusion systems will benefit 3D printing industry in drastically expanding the capability for long-term cell culture, disease modeling and drug testing on vascular tissues. The industry partner for this project, Aspect Biosystems, is a leading tech company providing solutions for bioprinting. These perfusion systems will benefit Aspect Biosystems in drastically expanding their capability for long-term cell culture, disease modeling and drug testing on vascular tissues. The advancement in the perfusion system will open up new markets and will improve company competitiveness.****