Microfluidic bioreactors for perfusion of 3D bioprinted tissues

用于灌注 3D 生物打印组织的微流体生物反应器

• 批准号: 535912-2018
• 负责人: Hejazi, SeyedHossein
• 金额: $ 1.82万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=653378
• 关键词: Microfluidic; bioreactors; perfusion; 3D; bioprinted

3D printing has changed the ways of practice in many applications including biomedical and tissue engineering. In particular, 3D printing is now used for the bioprinting of vascular tissues and drug delivery. The existing 3D bioprinters suffer from a mimetic delivery system, known as perfusion system, to provide nutrients to cell-laden bioprinted hydrogels. In partnership with one of the pioneering companies in 3D bioprinting, this research aims at developing a microfluidic based perfusion system for the delivery of nutrients, oxygen and drugs to 3D tissues. These perfusion systems will benefit 3D printing industry in drastically expanding the capability for long-term cell culture, disease modeling and drug testing on vascular tissues. The industry partner for this project, Aspect Biosystems, is a leading tech company providing solutions for bioprinting. These perfusion systems will benefit Aspect Biosystems in drastically expanding their capability for long-term cell culture, disease modeling and drug testing on vascular tissues. The advancement in the perfusion system will open up new markets and will improve company competitiveness.****

3D 打印改变了许多应用的实践方式，包括生物医学和组织工程。特别是，3D 打印现在用于血管组织和药物输送的生物打印。现有的 3D 生物打印机有一个模拟输送系统，称为灌注系统，为充满细胞的生物打印水凝胶提供营养。这项研究与 3D 生物打印领域的先驱公司之一合作，旨在开发一种基于微流体的灌注系统，用于向 3D 组织输送营养物质、氧气和药物。这些灌注系统将有利于 3D 打印行业，大幅扩展血管组织的长期细胞培养、疾病建模和药物测试的能力。该项目的行业合作伙伴 Aspect Biosystems 是一家提供生物打印解决方案的领先科技公司。这些灌注系统将有利于 Aspect Biosystems 大幅扩展其对血管组织进行长期细胞培养、疾病建模和药物测试的能力。灌注系统的进步将开拓新市场并提高公司竞争力。****