Interfacial Forces and Novel Self-Assembled Surface Structures
界面力和新型自组装表面结构
基本信息
- 批准号:RGPIN-2014-04076
- 负责人:
- 金额:$ 2.48万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The research in this proposal explores some of the fundamental processes that take place at interfaces. By interface, we mean the junction between two different phases of matter: here, the liquid-solid interface. The events that take place at solid-liquid interfaces are fundamental to, and indeed often dominate, many chemical processes that are of both academic and practical interest. For example, industrial synthesis of both bulk and fine chemicals; detection of biological molecules in medical devices; and many environmental processes can all take place at a solid-liquid interface.**One theme in this research is the detection and separation of chiral molecules. A chiral molecule is one which comes in two forms, which are literally mirror images of one another. The two forms have the same physical properties and so are difficult to detect. However, they react differently if they come into contact with another chiral molecule. Chiral molecules have more than academic interest: just about all biological systems are dominated by them. Consequently, many drug molecules are chiral. For example, the drug salbutamol, or ventolin(TM), used to treat asthma, comes in two chiral forms, referred to as the R- and S-enantiomer, and consists of a 50/50 mixture. The R-enantiomer is the active form, while the S-enantiomer is thought by some to produce many of the side effects associated with the drug. Such behaviour is associated with many pharmacological substances, and therefore developing means of detecting and separating chiral molecules is of great importance. Our research focuses on understanding the fundamental structure-property relationships that underlie the separation of the R and S versions of chiral molecules in a process known as chiral chromatography. **Our second research theme involves a previously unrecognized means of modifying surfaces using a process of self-assembly: here, a disordered system of molecules spontaneously evolves into an ordered structure, in this case a single layer (monolayer) of molecules at a surface. Our target class of molecule is called an N-heterocyclic carbene, or NHC. This class of molecule has been known for some time, and is often found as a component of various catalysts. But we have found that it may also be used to form a self-assembled monolayer on Au and potentially other metals, and can profoundly change the properties of the metal - including potential applications in optics, microelectronics and detection technologies. Furthermore, we have found that the carbon-metal bound NHC-based monolayers are potentially far more stable than the current state-of-the-art technologies in this area, which are based on a sulfur-metal chemical bond. NHC-based self-assembled systems are currently a big unknown, but ones which have the potential to revolutionize a number of technologies. In this research, we are intending to focus on both the fundamental aspects of the NHC self-assembly process, and also how an NHC film can be used to replace the sulfur-based chemistry in a biomedical detection technology known as surface plasmon resonance.**In summary, interfacial chemistry underlies processes as diverse as purifying mixtures of compounds, the detection of biomolecules, and the production of new photonic and electronic devices. We will address questions that will inform new approaches to these problems as we focus on both the development of new systems of self-assembly on surfaces and methodologies exploring the chemical interactions taking place at these surfaces. At any time, five PhD students and one undergraduate will be engaged in this research, preparing for careers in government or corporate laboratories, business or academia.
本提案中的研究探讨了界面上发生的一些基本过程。 通过界面,我们指的是物质两个不同相之间的连接处:这里是液-固界面。 固液界面发生的事件是许多具有学术和实际意义的化学过程的基础,而且实际上常常占主导地位。 例如,大宗化学品和精细化学品的工业合成;医疗器械中生物分子的检测;许多环境过程都可以在固液界面发生。**这项研究的一个主题是手性分子的检测和分离。 手性分子有两种形式,实际上是彼此的镜像。 这两种形式具有相同的物理特性,因此难以检测。 然而,如果它们与另一个手性分子接触,它们的反应会有所不同。 手性分子不仅仅具有学术兴趣:几乎所有生物系统都由它们主导。 因此,许多药物分子是手性的。 例如,用于治疗哮喘的药物沙丁胺醇或ventolin TM 有两种手性形式,称为R-和S-对映体,并且由50/50的混合物组成。 R-对映体是活性形式,而 S-对映体被一些人认为会产生许多与药物相关的副作用。 这种行为与许多药理物质有关,因此开发检测和分离手性分子的方法非常重要。 我们的研究重点是了解手性分子 R 和 S 版本在手性色谱过程中分离的基本结构-性质关系。 **我们的第二个研究主题涉及一种以前未被认识的利用自组装过程修改表面的方法:在这里,无序的分子系统自发地演变成有序的结构,在这种情况下是表面上的单层(单层)分子。 我们的目标分子类别称为 N-杂环卡宾,或 NHC。 这类分子已为人们所知有一段时间了,并且经常被发现作为各种催化剂的成分。 但我们发现它也可以用于在金和其他潜在金属上形成自组装单层,并且可以深刻改变金属的特性 - 包括在光学、微电子和检测技术中的潜在应用。 此外,我们发现碳-金属结合的 NHC 基单层可能比该领域目前基于硫-金属化学键的最先进技术稳定得多。 基于 NHC 的自组装系统目前还是一个很大的未知数,但它有可能彻底改变许多技术。 在这项研究中,我们打算重点关注 NHC 自组装过程的基本方面,以及如何在称为表面等离子体共振的生物医学检测技术中使用 NHC 薄膜取代硫基化学物质。**总而言之,界面化学是纯化化合物混合物、生物分子检测和新光子生产等多种过程的基础。 和电子设备。 我们将解决一些问题,这些问题将为解决这些问题提供新的方法,因为我们重点关注表面自组装新系统的开发和探索这些表面发生的化学相互作用的方法。 任何时候,都会有五名博士生和一名本科生从事这项研究,为政府或企业实验室、商界或学术界的职业生涯做好准备。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Horton, Joseph其他文献
Horton, Joseph的其他文献
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{{ truncateString('Horton, Joseph', 18)}}的其他基金
Fabrication, characterization and application of novel, highly stable, carbene-based self-assembled monolayers
新型、高度稳定的卡宾基自组装单分子层的制备、表征和应用
- 批准号:
RGPIN-2019-04038 - 财政年份:2022
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Fabrication, characterization and application of novel, highly stable, carbene-based self-assembled monolayers
新型、高度稳定的卡宾基自组装单分子层的制备、表征和应用
- 批准号:
RGPIN-2019-04038 - 财政年份:2021
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Fabrication, characterization and application of novel, highly stable, carbene-based self-assembled monolayers
新型、高度稳定的卡宾基自组装单分子层的制备、表征和应用
- 批准号:
RGPIN-2019-04038 - 财政年份:2020
- 资助金额:
$ 2.48万 - 项目类别:
Discovery Grants Program - Individual
Fabrication, characterization and application of novel, highly stable, carbene-based self-assembled monolayers
新型、高度稳定的卡宾基自组装单分子层的制备、表征和应用
- 批准号:
RGPIN-2019-04038 - 财政年份:2019
- 资助金额:
$ 2.48万 - 项目类别:
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Interfacial Forces and Novel Self-Assembled Surface Structures
界面力和新型自组装表面结构
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RGPIN-2014-04076 - 财政年份:2017
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Interfacial Forces and Novel Self-Assembled Surface Structures
界面力和新型自组装表面结构
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Interfacial Forces and Novel Self-Assembled Surface Structures
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Interfacial Forces and Novel Self-Assembled Surface Structures
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图论的应用
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$ 2.48万 - 项目类别:
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