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Obesity exacerbates ammonia-induced neurological dysfunction in cirrhosis

Obesity exacerbates ammonia-induced neurological dysfunction in cirrhosis
肥胖会加剧肝硬化中氨引起的神经功能障碍
批准号：
390212
负责人：
Rose Christopher
金额：
$51.27万
依托单位：
Centre hospitalier de l'Universit de Montral (CHUM)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-09-01 至 2023-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=390212&lang=en
关键词：
Ammonia Animal Models Behaviour Blood Brain Barrier Chronic Liver Disease Cirrhosis Glutamine Synthetase Hepatic Encephalopathy Microdialysis Obesity

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Hepatic encephalopathy (HE), characterized by cognitive, psychiatric and motor disturbances, is a devastating complication of liver disease. With as much as 80% of patients with cirrhosis suffering from HE, the burden of HE is immense considering its wide
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