Resources, Workforce Development, and Animal Models for the Rutgers RBL

罗格斯大学 RBL 的资源、劳动力发展和动物模型

• 批准号: 10793863
• 负责人: David Alland
• 金额: $ 397.07万
• 依托单位: RUTGERS BIOMEDICAL AND HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793863
• 关键词: 2019-nCoV; Address; Aftercare; Animal Husbandry; Animal Model; Animals; Bacillus anthracis; Biological Products; Budgets; COVID-19; Candida auris; Categories; Cells; Certification; Chikungunya virus; Collaborations; Communicable Diseases; Computers and Advanced Instrumentation; Containment; Cryptococcus; Development; Diagnostic; Diagnostics Research; Disasters; Disease model; Emergency response; Emerging Communicable Diseases; Ensure; Environment; Equipment; Equipment and supply inventories; Faculty; Francisella tularensis; Funding; Goals; Grant; HIV; Health; Impairment; Institution; Joints; Laboratories; Laboratory Research; Life Cycle Stages; Lung; Maintenance; Microbiology; Mission; Modeling; Monkeypox; Mycobacterium tuberculosis; Pathogenesis; Pathogenicity; Performance; Pharmacotherapy; Post-Acute Sequelae of SARS-CoV-2 Infection; Procedures; Research; Research Activity; Research Contracts; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Safety; Scientist; Services; Shipping; System; Therapeutic; Tissues; Training; Tuberculosis; United States; United States National Institutes of Health; Universities; Viral; Virulent; Waste Management; Work; Workforce Development; Yersinia pestis; biosecurity; biothreat; cost; end of life; improved; influenzavirus; laboratory facility; operation; pandemic disease; pandemic preparedness; pathogen; public health emergency; recruit; response; tuberculosis drugs; tuberculosis treatment; viral transmission; virology

Overall ABSTRACT The Rutgers University Regional Biocontainment Laboratory (RBL) serves as a central facility to perform biosafety level three (BSL3) therapeutic, pathogenesis, and diagnostic research on high threat biological agents with a focus on Mycobacterium tuberculosis and SARS-CoV-2, as well as other category A, B, and C pathogens. The RBL serves academic and commercial entities within Rutgers University, the Northeast United States and nationally, while also engaging globally with companies and academic institutions through collaborations and research contracts. This proposal will provide support that enhances the RBL’s ability to fulfill its research and biothreat response/pandemic preparedness missions while also supporting an expanding faculty/staff. We propose to accomplish these goals by improving the RBL facilities, support services, BSL3 practice development and implementation and special services offerings though the execution of three aims: Aim 1. Establish a Facility management, maintenance and operations (FMMO) core. Aim 2. Establish a BSL-3 Practices core (Practice core). Aim 3. Establish a biocontainment research support service core devoted to developing animal models of BSL3 pathogens and associated support services (Animal models and related services, or AMRS core). The FMMO core will provide BSL3 and ABSL3 services, management and oversight, for routine animal husbandry, microbiology and virology services in support of investigators grant funded research projects while ensuring efficient operations and maintenance of the BSL3 facilities and providing trained staff to support the BSL3 building systems and equipment. The Practice core will develop and maintain standard operating procedures and training for research in the RBL BSL3 laboratories including best practices, emergency response, waste management, shipping, husbandry, select agent-specific practices and inventory. It will also develop and conduct biosecurity and disaster drills and liaise with other BSL3 laboratories within the RBL network as well as local, state and federal health agencies to coordinate operations and plan for joint responses to new infectious disease threats. The AMRS core will develop critical animal models including those of SARS-CoV2 and highly pathogenic influenza virus transmission, COVID-19 PASC, pulmonary impairment after TB (PIAT), and drug treatment models, and then support grant funded investigators in the performance of these models along with the advanced instrumentation needed to analyze these infected models and their tissues/cells in a BSL3 environment. Together, these three cores will significantly enhance the near- and long-term abilities of the RBL to address critical biothreats and emerging infectious diseases requiring study in a BSL3 laboratory setting, while also increasing our capacity to respond to the next public health emergency or pandemic.

总体摘要 罗格斯大学区域生物防护实验室（RBL）作为一个中心设施， 生物安全三级（BSL 3）高威胁生物制剂的治疗、发病机理和诊断研究 重点是结核分枝杆菌和SARS-CoV-2，以及其他A、B和C类病原体。 RBL服务于罗格斯大学，美国东北部和 在全国范围内，同时也通过合作与全球公司和学术机构合作， 研究合同。该提案将提供支持，提高RBL完成研究的能力， 生物威胁应对/大流行病防备任务，同时还支持不断扩大的教职员工。我们 建议通过改善RBL设施、支持服务、BSL 3实践开发来实现这些目标 和实施和特殊服务的提供，通过执行三个目标：目标1。建立一个设施 管理、维护和运营（FMMO）核心。目标2.建立BSL-3实践核心（实践 核心）。目标3。建立一个生物防护研究支持服务中心，致力于开发动物模型， BSL 3病原体和相关支持服务（动物模型和相关服务，或AMRS核心）。的 FMMO核心将为常规畜牧业提供BSL 3和ABSL 3服务、管理和监督， 支持研究人员的微生物学和病毒学服务，在确保 BSL 3设施的有效运行和维护，并提供训练有素的工作人员来支持BSL 3 建筑系统和设备。业务核心将制定和维持标准作业程序 RBL BSL 3实验室的研究培训，包括最佳实践，应急响应，废物处理 管理、运输、饲养、选择代理特定的实践和库存。它还将发展和进行 生物安全和灾难演习，并与RBL网络内的其他BSL 3实验室以及当地， 州和联邦卫生机构协调行动并计划联合应对新的传染病 威胁AMRS核心将开发关键动物模型，包括SARS-CoV 2和高致病性动物模型。 流感病毒传播、COVID-19 PASC、结核病后肺损害（PIAT）和药物治疗 模型，然后支持赠款资助的研究人员在这些模型的性能沿着先进的 在BSL 3环境中分析这些感染模型及其组织/细胞所需的仪器。 总之，这三个核心将大大提高RBL的近期和长期能力，以解决 需要在BSL 3实验室环境中进行研究的重大生物威胁和新出现的传染病，同时 提高我们应对下一次突发公共卫生事件或大流行病的能力。