Enzymatic Nanocellulose for Antibiofilm Applications

用于抗菌膜应用的酶纳米纤维素

• 批准号: 530841-2018
• 负责人: Impellizzeri, Stefania
• 金额: $ 1.82万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=654250
• 关键词: Enzymatic; Nanocellulose; Antibiofilm; Applications

Ocean-dependent activities make a substantial contribution to the Canadian economy. However, accumulation**and adhesion of microorganisms on wetted surfaces and their systematic organization into stable, coordinated,**resilient communities (biofilms) costs the Canadian marine industry billions of dollars each year in equipment**damage, energy losses and product contamination (biofouling). It follows that new, effective, and**environmentally compatible options are needed to control fouling.**BIOSA TECHNOLOGIES LTD is a company specializing in enzymatic biotechnology. Currently, BIOSA**TECHNOLOGIES LTD is looking to combine their adapted enzymes with advanced, customized**nanomaterials for the fabrication of anti-biofilm coatings for marine equipment and installations. To address**the company's need, we propose the development of environmentally benign, non-toxic and industrially**sustainable enzyme-modified nanocellulose with antimicrobial and antifouling properties. With environmental**concerns over sustainability and end-of-life disposal challenges on the rise, we suggest that functional 'green'**materials derived from renewable resources such as cellulose represent a viable and effective solution to the**company's specific problem, offering low maintenance and lifecycle costs, stability, reusability, substrate and**product specificity.**Canada has the longest coastline and the fourth largest ocean territory in the world; maritime resources are**one of our most significant assets. Indeed, enormous potential exists to better leverage science and technology**in Canada's ocean sectors and to build an innovative, knowledge-based ocean economy. The outcomes of this**project - which follows a multidisciplinary approach at the interface of chemistry, biology and nanotechnology**- are expected not only to contribute to Canadian excellence and competitiveness through the invention of a**completely novel, efficient and sustainable bionanotechnology, but also to lead to the creation of Canadian**intellectual property with great potential for commercialization.

依赖海洋的活动对加拿大经济作出了重大贡献。然而，微生物在潮湿表面上的积累和粘附以及它们系统地组织成稳定、协调、有弹性的群落（生物膜），每年使加拿大海洋工业在设备损坏、能源损失和产品污染（生物污损）方面损失数十亿美元。因此，需要新的、有效的和 ** 环境兼容的选择来控制污垢。BIOSA生物技术有限公司是一家专门从事酶生物技术的公司。目前，BIOSA** 生物技术有限公司正在寻求将其适应性酶与先进的定制 ** 纳米材料相结合，用于制造海洋设备和装置的抗生物膜涂层。为了满足 ** 公司的需求，我们建议开发环境友好，无毒和工业 ** 可持续的酶改性纳米纤维素，具有抗菌和抗菌性能。随着对可持续性和报废处理挑战的环境关注的增加，我们建议从可再生资源（如纤维素）中提取的功能性“绿色"材料是解决 ** 公司特定问题的可行且有效的解决方案，提供低维护和生命周期成本，稳定性，可重复使用性，基材和 ** 产品特异性。加拿大拥有世界上最长的海岸线和第四大海洋领土;海洋资源是我们最重要的资产之一。事实上，在加拿大海洋部门更好地利用科学和技术 ** 和建立创新的知识型海洋经济方面存在着巨大的潜力。该项目的成果-在化学、生物学和纳米技术的界面上采用多学科方法-预计不仅将通过发明一种完全新颖、有效和可持续的生物纳米技术，为加拿大的卓越和竞争力做出贡献，而且还将导致创造具有巨大商业化潜力的加拿大知识产权。