Wavefront Sensorless and Computational Adaptive Optics for High Resolution Imaging

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***The purpose of this research proposal is to investigate novel optical techniques to advance the state of the art for cellular resolution ophthalmic imaging in humans. Specifically, wavefront sensorless adaptive optics based techniques will be investigated for ophthalmic OCT imaging through the following two objectives:***Objective 1: Closed-loop wavefront sensorless adaptive optics (WSAO) OCT for cellular resolution retinal imaging:***WSAO OCT overcomes the issues associated with conventional wavefront sensor, by directly using the image quality metric as a merit function for aberration correction. Despite its success in both preclinical and clinical imaging, WSAO is limited by time needed for the algorithm to perform the wavefront correction, and cannot account for temporal changes of the wavefront aberrations. Novel methods in WSAO optimization algorithm will be investigated to decrease the optimization time in order to perform closed-loop aberration correction.***Objective 2: Parallel wavefront sensorless adaptive optics assisted wide field of view retinal imaging:***AO retinal imaging's limited field of view is preventing its widespread adaptation in clinical environment. It has been well established that the exquisite spatial resolution afforded by AO is useful for clinical application, however, the diagnosis of many retinal diseases depend upon large field imaging of the retina. Novel parallel WSAO aberration correction will be investigated to apply different aberration correction profiles determined by the combination of optical modeling and simultaneous parallel WSAO optimization at different retinal eccentricities.***The potential impact of my research program in Biophotonics is to improve imaging technology for clinical ophthalmic diagnosis, and to create novel tools to accelerate vision research in the preclinical development of experimental therapies for vision robbing diseases.