Wavefront Sensorless and Computational Adaptive Optics for High Resolution Imaging

这项研究提案的目的是研究新的光学技术，以促进人类细胞分辨率眼科成像的技术水平。具体地说，基于波前无传感器自适应光学技术的眼科OCT成像将通过以下两个目标进行研究： 目标1：用于细胞分辨率视网膜成像的闭环波前无传感器自适应光学(WSAO)OCT： WSAO OCT通过直接使用图像质量度量作为像差校正的价值函数，克服了与传统波前传感器相关的问题。尽管WSAO在临床前和临床成像方面都取得了成功，但它受到算法执行波前校正所需时间的限制，并且无法解释波前像差的时间变化。将研究WSAO优化算法中的新方法，以减少优化时间，从而进行闭环像差校正。 目的2：平行波前无传感器自适应光学辅助大视野视网膜成像： AO视网膜成像的有限视野限制了其在临床环境中的广泛适应。众所周知，光学显微镜所提供的精细的空间分辨率在临床上是有用的，然而，许多视网膜疾病的诊断依赖于视网膜的大视野成像。新的并行WSAO像差校正将在不同的视网膜偏心率下应用由光学建模和同步并行WSAO优化相结合确定的不同像差校正轮廓。 我的生物光子学研究计划的潜在影响是改进临床眼科诊断的成像技术，并在视觉抢夺疾病的实验疗法的临床前开发中创造新的工具来加速视觉研究。

The purpose of this research proposal is to investigate novel optical techniques to advance the state of the art for cellular resolution ophthalmic imaging in humans. Specifically, wavefront sensorless adaptive optics based techniques will be investigated for ophthalmic OCT imaging through the following two objectives: Objective 1: Closed-loop wavefront sensorless adaptive optics (WSAO) OCT for cellular resolution retinal imaging: WSAO OCT overcomes the issues associated with conventional wavefront sensor, by directly using the image quality metric as a merit function for aberration correction. Despite its success in both preclinical and clinical imaging, WSAO is limited by time needed for the algorithm to perform the wavefront correction, and cannot account for temporal changes of the wavefront aberrations. Novel methods in WSAO optimization algorithm will be investigated to decrease the optimization time in order to perform closed-loop aberration correction. Objective 2: Parallel wavefront sensorless adaptive optics assisted wide field of view retinal imaging: AO retinal imaging’s limited field of view is preventing its widespread adaptation in clinical environment. It has been well established that the exquisite spatial resolution afforded by AO is useful for clinical application, however, the diagnosis of many retinal diseases depend upon large field imaging of the retina. Novel parallel WSAO aberration correction will be investigated to apply different aberration correction profiles determined by the combination of optical modeling and simultaneous parallel WSAO optimization at different retinal eccentricities. The potential impact of my research program in Biophotonics is to improve imaging technology for clinical ophthalmic diagnosis, and to create novel tools to accelerate vision research in the preclinical development of experimental therapies for vision robbing diseases.