Optimal and Sub-Optimal Flow Configurations in the Heart: Application to Implantable Medical Devices

心脏中的最佳和次最佳血流配置：在植入式医疗设备中的应用

• 批准号: RGPIN-2017-06716
• 负责人: Kadem, Lyes
• 金额: $ 2.7万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=654971
• 关键词: Optimal; Sub; Flow; Configurations; Heart

Cardiovascular disease is currently responsible for more than 17 million deaths per year worldwide, corresponding to about 30% of all deaths combined. Furthermore, it is projected that cardiovascular disease is to remain the leading cause of mortality by 2030. In order to restrain the negative impacts of cardiovascular disease on the population and the economy, there is an urgent need to promote innovation in medical devices. However, despite a consistent annual growth of the Canadian medical device industries, their market share remains very low. This is part due to the lack of sufficient medical device expertise and skills. This proposed research program has the potential to significantly contribute towards resolving this gap. This is by generating unique knowledge and data that should trigger innovation in implantable medical devices and train highly qualified personnel with strong fundamental knowledge and skills in cardiovascular fluid dynamics applied to implantable medical devices. The proposed research program is designed around three main research axes. In the research axis#1, we will determine experimentally the range of anatomical and flow design parameters associated with optimal flow performance in heart cavities. This is expected to lead to significant advances in the design of new innovative left ventricle assist devices and 3D bioprinting of artificial organs. In the research axis#2, we will investigate, experimentally and mathematically, the complex flow dynamics in heart cavities in the presence of mixed and multiple valve pathologies in order to advance our knowledge on the real flow environment of implantable medical devices and optimize their testing and selection criteria. In the research axis#3, we will be developing the next-generation of cardiac simulators based on patient-specific data and anatomy: “3D-printed patient clones”. The expected impact will be a significant advancement in close-to-real testing of implantable medical devices. This research program has the potential to contribute towards improving current guidelines and standards for market approval of implantable medical devices, lowering the costs of development and promoting innovation in Canada.

心血管疾病目前每年造成全球超过1700万人死亡，相当于所有死亡总数的约30%。此外，据预测，到2030年，心血管疾病仍将是死亡的主要原因。为了抑制心血管疾病对人口和经济的负面影响，迫切需要促进医疗器械的创新。然而，尽管加拿大医疗器械行业每年都在持续增长，但其市场份额仍然很低。部分原因是缺乏足够的医疗器械专业知识和技能。这项拟议的研究计划有可能为解决这一差距做出重大贡献。这是通过生成独特的知识和数据，这些知识和数据应该触发植入式医疗器械的创新，并培养具有应用于植入式医疗器械的心血管流体动力学方面的强大基础知识和技能的高素质人才。拟议的研究计划是围绕三个主要研究轴设计的。在研究轴#1中，我们将通过实验确定与心腔中最佳流动性能相关的解剖和流动设计参数范围。预计这将导致新的创新左心室辅助装置和人工器官3D生物打印的设计取得重大进展。在研究轴#2中，我们将通过实验和数学方法研究存在混合和多种瓣膜病变的心脏腔中的复杂流动动力学，以提高我们对植入式医疗器械的真实的流动环境的认识，并优化其测试和选择标准。在研究轴#3中，我们将基于患者特定数据和解剖结构开发下一代心脏模拟器：“3D打印患者克隆”。预期的影响将是植入式医疗器械接近真实的测试的重大进步。该研究计划有可能有助于改善植入式医疗器械市场批准的现行指南和标准，降低开发成本并促进加拿大的创新。