Investigating mechanisms of action of silver oxynitrate: an unexplored silver compound with superior anti-biofilm activity.

研究硝酸氧银的作用机制：一种未经开发的银化合物，具有优异的抗生物膜活性。

• 批准号: 501022-2016
• 负责人: Khursigara, Cezar
• 金额: $ 3.9万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=655491
• 关键词: Investigating; mechanisms; action; silver; oxynitrate

Silver has been used as an antimicrobial compound for thousands of years. Although interest in silver waned in the 1940s with the advent of antibiotic technologies, incidence of antibiotic resistance led to a resurgence in silver antimicrobial technologies in the 1980s. Since then, a variety of silver compounds have been used in topical antimicrobial applications, however, there is still no consensus on the efficacy of silver and mechanistic studies of silver activity are restrictive to singly ionic silver. As a consequence, silver compounds have a tarnished reputation. This project will be the first investigation into mechanisms of action and resistance for a range of silver compounds including the novel silver oxynitrate. Differentiating silver mechanisms of action and antimicrobial resistance will provide a greater understanding of efficacy, establishing structure for consensus, clinical use, and new technological developments. These findings will provide clinicians and patients with effective options for the management of antibiotic resistant infections. Resulting in lessened incidence of infection and associated costs, currently estimated at CAD$ 1 Billion, within the Canadian Health Care System.**

白银已被用作抗菌化合物已有数千年了。尽管随着抗生素技术的出现，对白银的兴趣在1940年代逐渐减弱，但抗生素耐药性的发生导致1980年代银抗菌技术的复兴。从那时起，多种银化合物已在局部抗菌剂应用中使用，但是，关于银的疗效和银活性的机理研究仍然限制了单位离子银。结果，银化合物的声誉受损。该项目将是对包括新型银氧硝酸盐在内的一系列银化合物的作用机理和抗性机理的首次研究。区分作用和抗菌抗性的银机理将为有效性，建立共识，临床使用和新技术发展提供更多了解。这些发现将为临床医生和患者提供有效治疗抗生素耐药性感染的选择。导致加拿大医疗保健系统内的感染和相关成本的发病率减少，目前估计为10亿加元。**