Investigating mechanisms of action of silver oxynitrate: an unexplored silver compound with superior anti-biofilm activity.

数千年来，银一直被用作抗微生物化合物。虽然在20世纪40年代随着抗生素技术的出现，对银的兴趣减弱，但抗生素耐药性的发生导致银抗菌技术在20世纪80年代复苏。从那时起，各种银化合物已被用于局部抗微生物应用，然而，关于银的功效仍然没有共识，并且银活性的机理研究局限于单离子银。因此，银化合物的声誉受损。该项目将是第一个调查的作用机制和阻力的范围银化合物，包括新的银硝酸氧。区分银的作用机制和抗菌剂耐药性将有助于更好地了解疗效，建立共识结构，临床使用和新技术开发。这些发现将为临床医生和患者提供管理抗生素耐药感染的有效选择。导致感染发生率和相关费用减少，目前估计在加拿大卫生保健系统内为10亿加元。

Silver has been used as an antimicrobial compound for thousands of years. Although interest in silver waned in the 1940s with the advent of antibiotic technologies, incidence of antibiotic resistance led to a resurgence in silver antimicrobial technologies in the 1980s. Since then, a variety of silver compounds have been used in topical antimicrobial applications, however, there is still no consensus on the efficacy of silver and mechanistic studies of silver activity are restrictive to singly ionic silver. As a consequence, silver compounds have a tarnished reputation. This project will be the first investigation into mechanisms of action and resistance for a range of silver compounds including the novel silver oxynitrate. Differentiating silver mechanisms of action and antimicrobial resistance will provide a greater understanding of efficacy, establishing structure for consensus, clinical use, and new technological developments. These findings will provide clinicians and patients with effective options for the management of antibiotic resistant infections. Resulting in lessened incidence of infection and associated costs, currently estimated at CAD$ 1 Billion, within the Canadian Health Care System.**