Developing and evaluating new nano-delivery vehicles for natural health antimicrobials

开发和评估用于天然健康抗菌药物的新型纳米递送载体

• 批准号: 484197-2015
• 负责人: Khursigara, Cezar
• 金额: $ 1.82万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=584171
• 关键词: Developing; evaluating; new; nano; delivery

The Public Health Agency of Canada estimates that roughly one in eight Canadians (or four million people) get sick each year due to domestically acquired foodborne diseases. This is estimated to cost the Canadian economy more than $2 billion per year. A common source of domestic infections is poorly handled and contaminated foods materials, and bacterial pathogens such as Salmonella enterica, Clostridium perfringens, Escherichia coli and Listeria monocytogenes account for approximately 90% of these illnesses. Therefore, there is a pressing need to develop nontoxic and effective disinfectant agents that can be safely used in kitchens across Canada. EastGate Pharmaceuticals recognizes the importance of reducing the exposure of these pathogens and aims to design natural consumer products that will limit their spread. Recently, they have developed a nano-delivery-based line of antimicrobial hand sanitizers and fruit and vegetable washing solutions derived from natural, non-toxic ingredients. The initial formulations of these antimicrobials have demonstrated limited activities against common foodborne bacterial pathogens. By collaborating with Dr. Khursigara at the University of Guelph, EastGate aims to improve the nano-delivery mechanism of their natural antimicrobials to enhance their antibacterial activities. Dr. Khursigara's team will use existing antimicrobial testing guidelines that have been established by Health Canada and Public Health Ontario to assess the efficacy of the novel antimicrobial formulations against these bacterial pathogens. EastGate Pharmaceuticals will use this information to develop better antimicrobial formulations and nano-delivery mechanisms that could potentially be adapted to safely deliver other types of drugs in the human body.

加拿大公共卫生署估计，每年大约有八分之一的加拿大人（或400万人）因国内获得的食源性疾病而患病。据估计，这将使加拿大经济每年损失超过20亿美元。家庭感染的一个常见来源是处理不当和污染的食品材料，细菌病原体如沙门氏菌、产气荚膜梭菌、大肠杆菌和单核细胞增生李斯特菌约占这些疾病的90%。因此，迫切需要开发无毒和有效的消毒剂，可以安全地用于加拿大各地的厨房。EastGate Pharmaceuticals认识到减少这些病原体暴露的重要性，并旨在设计限制其传播的天然消费品。最近，他们开发了一种基于纳米递送的抗菌洗手液和水果蔬菜洗涤液系列，这些产品来自天然无毒成分。这些抗菌剂的初始制剂对常见食源性细菌病原体的活性有限。通过与圭尔夫大学的Khursigara博士合作，EastGate旨在改善其天然抗菌剂的纳米递送机制，以增强其抗菌活性。Khursigara博士的团队将使用加拿大卫生部和安大略公共卫生部制定的现有抗菌测试指南来评估新型抗菌制剂对这些细菌病原体的有效性。EastGate Pharmaceuticals将利用这些信息开发更好的抗菌制剂和纳米递送机制，这些机制可能适用于在人体内安全递送其他类型的药物。